职称：教授

邮箱：nianliu1995@163.com

地址：河南省郑州市二七区大学北路40号医学科学院博后楼401

个人简介

刘念，郑州大学医学科学院、天健先进生物医学实验室（郑州大学）学科特聘教授，硕士生导师。毕业于中国科学院生物物理研究所，主要从事肠道免疫稳态维持的机制研究，聚焦于固有淋巴样细胞，探究肠道黏膜免疫与微环境-免疫互作调控的分子机制。以第一或通讯作者（含共同）在Nature Immunology、Nature Communications、Cellular&Molecular Immunology等期刊发表多篇研究论文。目前承担国家自然科学面上项目、青年科学基金[C类]等多个项目。

代表性论文

1、Nian Liu^#, Jiacheng He^#, Yanmei Yang^#, Yunlong Wang^#, Lingwei Zhang^#, Ziqi Xiao, Zhen Xiong, Shangxun Zhong, Yuwei Xu, Yang Gu, Jianyi Wang, Yufei Lan, Ying Du, Pingping Zhu, Zhi Zhang, Xinjuan Fan^*, Benyu Liu^*, Zusen Fan^*. Enteric GABAergic neurons-derived γ-aminobutyric acid initiates expression of Igfbp7 to sustain ILC3 homeostasis. Nature Immunology. 2025.

2、Lingwei Zhang^#, Hong Chen^#, Yangmei Yang^#, Liangbo Zhao, Huimin Xie, Peixian Li, Xinrui Lv^*, Luyun He, Nian Liu^* & Benyu Liu^*. Targeting LINC02320 prevents colorectal cancer growth via GRB7-dependent inhibition of MAPK signaling pathway. Cellular & Molecular Biology Letters. 2025.

3、Yang Gu^#, Zhibin Yi^#, Ziheng Zhou^#, Jianyi Wang^#, Shan Li^#, Pingping Zhu, Nian Liu, Yuwei Xu, Lei He, Yanying Wang & Zusen Fan SNORD88B-mediated WRN nucleolar trafficking drives self-renewal in liver cancer initiating cells and hepatocarcinogenesis. Nature Communications. 2024.

4、Nian Liu^#, Jiacheng He^#, Dongdong Fan^#, Yang Gu, Jianyi Wang, Huimu Li, Xiaoxiao Zhu, Ying Du, Yong Tian, Benyu Liu, Zusen Fan. Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription. Nature Communications. 2022.

5、Buqing Ye^#, Liuliu Yang^#, Benyu Liu^#, Nian Liu^#, Dongdong Fan^#, Huimu Li, Lei Sun, Ying Du, Shuo Wang, Yong Tian, Zusen Fan. Induction of functional neutrophils from mouse fibroblasts by thymidine through enhancement of Tet3 activity. Cellular&Molecular Immunology. 2022.

6、Benyu Liu^#, Nian Liu^#, Xiaoxiao Zhu^#, Liuliu Yang, Buqing Ye, Huimu Li, Pingping Zhu, Tiankun Lu, Yong Tian, Zusen Fan. Circular RNA circZbtb20 maintains ILC3 homeostasis and function via Alkbh5-dependent m6A demethylation of Nr4a1 mRNA. Cellular&Molecular Immunology. 2021.