邮箱：qianyz87@zzu.edu.cn

地址：河南省郑州市科学大道100号

个人简介

2025年6月毕业于郑州大学，获得生物学学位。2025年12月入职郑州大学医学前沿交叉学院助理教授。

主要研究方向

肿瘤免疫治疗及多肽药物研究

荣誉及获奖情况

2026年，国家自然科学基金-青年项目（C类）

2026年，中国博士后科学基金会第79批面上资助项目

代表性成果

(1)Yuzhen Oian^#, Qiongqiong Zhang^#, Yahong Wu, Yixuan Sun, Ying Cheng, Peishang Shi, Qingchao Wang, Lu Qiu, Mingshuang Wang, Wenshan Zhao, Wenjie Zhai, Lingling Li. A novel peptide blocking CD93/IGFBP7 interaction normalizes tumor vessels and synergizes with radiotherapy for cancer immunotherapy. Pharmacol Res. 2026 Mar:225:108118.

(2)Yuzhen Qian^#, Yixuan Sun^#, Yahong Wu, Yi Liu, Xiuman Zhou Haoming Ning, Youmei Xiao, Xueqin Zhu, Xuefu Zhou, Xiaoshuang Niu, Wenjie Zhai, Yanfeng Gao. A Bispecific Peptide-Drug Conjugate Targeting LAG-3 and PD-L1 Harnesses Antitumor Immunity of Macrophages and T Cells. J Med Chem. 2026 Apr 9;69(7):7839-7855.

(3)Yuzhen Qian^#, Yixuan Sun^#, Peishang Shi, Xiuman Zhou, Qiongqiong Zhang, Qingyu Dong, Shengzhe Jin, Lu Qiu, Xiaoshuang Niu, Xiaowen Zhou, Wenshan Zhao, Yahong Wu, Wenjie Zhai, Yanfeng Gao. Development of LAG-3/FGL1 blocking peptide and combination with radiotherapy for cancer immunotherapy. Acta Pharm Sin B. 2024 Mar;14(3):1150-1165.

(4)Peng Sang^#, Jiacheng Wei^#, Yuzhen Qian^#, Mingshuang Wu, Tingting Song, Wenrui Li, Jinghui Wei, Baoguo Li, Jian Zhang, Jianfeng Cai, Yan Shi. Inhibition of Wnt Signaling Using Axin Peptidomimetics through Direct Targeting of β‑Catenin. J Med Chem. 2026 Apr 9;69(7):8583-8598.

(5)Xiuman Zhou^#, Yuzhen Qian^#, Chen Ling^#, Zhuoying He, Peishang Shi, Yanfeng Gao, Xinghua Sui. An integrated framework for prognosis prediction and drug response modeling in colorectal liver metastasis drug discovery. J Transl Med. 2024 Mar 30;22(1):321.