职称：副教授

      电话：0371-66658832

      邮箱：jiangeqiu@zzu.edu.cn

      地址：河南省郑州市二七区大学北路40号郑州大学河南医学院

个人简介

邱建阁副教授，女，汉族，理学博士，郑州大学拔尖博士和郑州大学青年骨干教师，硕士生导师。长期关注肿瘤发生发展及治疗抵抗的机制研究以及小分子抗肿瘤药物研究。主持国家自然科学基金、中国博士后基金和河南省高等学校重点科研项目等。博士研究生期间作为国家留学基金委公派联合培养博士研究生在美国俄亥俄州University of Cincinnati（辛辛那提大学）药理系进行了近2年的访问学习。目前已在Drug Resistance Updates、Cancer letters、Nano Letters、Chemical Science、Sensors and Actuators B: Chemical、British Journal of Pharmacology、Analytical Chemistry、Trends In Pharmacological Sciences、Drug Discovery Today和Frontiers on Pharmacology等杂志发表SCI论文60多篇，其中中国科学院一区期刊论文20篇。Analytical Chemistry和Frontiers in Oncology等SCI杂志审稿人。已指导培养博士及硕士研究生8人。

主要研究方向

      肿瘤发生发展及治疗抵抗的机制研究以及小分子抗肿瘤药物研究

代表性成果

1.Zhang Y, Qiu JG, Jia XY, Ke Y, Zhang MK, Stieg D, Liu WJ, Liu LZ, Wang L, Jiang BH. METTL3-mediated N6-methyladenosine modification and HDAC5/YY1 promote IFFO1 downregulation in tumor development and chemo-resistance. Cancer Lett 2023, 553: 215971.

2.Wang L, Yong YL, Wang KK, Xie YX, Qian YC, Zhou FM, Qiu JG, Jiang BH. MKRN2 knockout causes male infertility through decreasing STAT1, SIX4, and TNC expression. Front Endocrinol (Lausanne) 2023, 14: 1138096.

3.Wang L, Zhou ZH, Xie YX, Liu WJ, Zhang RX, Jiang N, He ML, Qiu JG, Jiang BH. Dysregulation of MiR-199a/IL8 pathway in chronic Cr (VI)-induced tumor growth and angiogenesis. Ecotoxicol Environ Saf 2023, 262: 115155.

4.Qiu J, Li Q, Li J, Zhou F, Sang P, Xia Z, Wang W, Wang L, Yu Y, Jiang J. Complementary roles of EP2 and EP4 receptors in malignant glioma. Br J Pharmacol 2023.

5.Liu WJ, Wang L, Zhou FM, Liu SW, Wang W, Zhao EJ, Yao QJ, Li W, Zhao YQ, Shi Z, Qiu JG, Jiang BH. Elevated NOX4 promotes tumorigenesis and acquired EGFR-TKIs resistance via enhancing IL-8/PD-L1 signaling in NSCLC. Drug Resist Updat 2023, 70: 100987.

6.Liu M, Zhang D, Hu JP, Wang LJ, Qiu JG, Zhang CY. Construction of bidirectional strand displacement-driven three-dimensional DNA walkers for single-molecule monitoring of multiple DNA glycosylases. Sensor Actuat B-Chem 2023, 380.

7.Liu BJ, Li FF, Xie YX, Fan CY, Liu WJ, Qiu JG, Jiang BH. miR-196a Upregulation Contributes to Gefitinib Resistance through Inhibiting GLTP Expression. Int J Mol Sci 2022, 23(3).

8.Wang LJ, Han Q, Qiu JG, Zhang CY. Cooperative In Situ Assembly of G-Quadruplex DNAzyme Nanowires for One-Step Sensing of CpG Methylation in Human Genomes. Nano Lett 2022, 22(1): 347-354.

9.Wang ZY, Yuan H, Li DL, Hu J, Qiu JG, Zhang CY. Hydroxymethylation-Specific Ligation-Mediated Single Quantum Dot-Based Nanosensors for Sensitive Detection of 5-Hydroxymethylcytosine in Cancer Cells. Anal Chem 2022, 94(27): 9785-9792.

10.Wang L, Liu H, Li X, Meng Y, Qiu J, Zhang C. Methylation-powered engineering of a dual-color light-up RNA nanosensor for label-free and ultrasensitive sensing of multiple DNA methyltransferases. Sensors and Actuators B-Chemical 2022, NOV 15.

11.Liu M, Qiu JG, Ma F, Zhang CY. Advances in single-molecule fluorescent nanosensors. Wiley Interdiscip Rev Nanomed Nanobiotechnol 2021, 13(5): e1716.

12.Liu WJ, Huang YX, Wang W, Zhang Y, Liu BJ, Qiu JG, Jiang BH, Liu LZ. NOX4 Signaling Mediates Cancer Development and Therapeutic Resistance through HER3 in Ovarian Cancer Cells. Cells 2021, 10(7).

13.Xia ZK, Wang W, Qiu JG, Shi XN, Li HJ, Chen R, Ke KB, Dong C, Zhu Y, Wu SG, Zhang RP, Meng ZR, Zhao H, Gu P, Leung KS, Wong MH, Liu XD, Zhou FM, Zhang JY, Yao YT, Wang SJ, Zhang CY, Qin YR, Lin MC, Jiang BH. Discovery of a New CDK4/6 and PI3K/AKT Multiple Kinase Inhibitor Aminoquinol for the Treatment of Hepatocellular Carcinoma. Front Pharmacol 2021, 12: 691769.

14.Qiu JG, Wang L, Liu WJ, Wang JF, Zhao EJ, Zhou FM, Ji XB, Wang LH, Xia ZK, Wang W, Lin MC, Liu LZ, Huang YX, Jiang BH. Apigenin Inhibits IL-6 Transcription and Suppresses Esophageal Carcinogenesis. Front Pharmacol 2019, 10: 1002.

15.Qiu J, Li Q, Bell KA, Yao X, Du Y, Zhang E, Yu JJ, Yu Y, Shi Z, Jiang J. Small-molecule inhibition of prostaglandin E receptor 2 impairs cyclooxygenase-associated malignant glioma growth. Br J Pharmacol 2019, 176(11): 1680-1699.

16.Wang L, Qiu JG, He J, Liu WJ, Ge X, Zhou FM, Huang YX, Jiang BH, Liu LZ. Suppression of miR-143 contributes to overexpression of IL-6, HIF-1alpha and NF-kappaB p65 in Cr(VI)-induced human exposure and tumor growth. Toxicol Appl Pharmacol 2019, 378: 114603.