职称：讲师

        电话：0371-67967671

        邮箱：zhaolijuan@zzu.edu.cn或xiaoye1695651408@163.com

        地址：郑州大学 医学科学院 省部共建食管癌防治国家重点实验室302室

个人简介

2020年-至今 郑州大学医学科学院，省部共建食管癌防治国家重点实验室，讲师。

2014年-2020年 郑州大学药学院，医学博士

2020年-2014年 郑州大学药学院，理学学士

主要研究方向

主要从事抗肿瘤药理研究，肿瘤外泌体研究，肿瘤的表观遗传调控研究，及表观遗传对肿瘤免疫微环境的调控作用研究。

代表性成果

1.LSD1通过LSD1/ miR-143-5P/SLC7A11轴促进Erastin诱导的胃癌细胞铁死亡及机制研究，中国博士后科学基金会，面上项目， 2021M702942（主持）

2.Xing-Jie Dai^#; Li-Juan Zhao^#; Long-Hua Yang^#; Ting Guo; Lei-Peng Xue; Hong-Mei Ren; Zhi-Li Yin; Xiao-Peng Xiong; Ying Zhou; Shi-Kun Ji; Hui-Min Liu; Hong-Min Liu^*; Ying Liu^*; Yi-Chao Zheng^*; Phenothiazine-Based LSD1 Inhibitor Promotes T-Cell Killing Response of Gastric Cancer Cells, Journal of Medicinal Chemistry, 2023, 66(6):3896-3916.

3.M A A Mamun, Yu Zhang, Jin-Yuan Zhao, Dan-Dan Shen, Ting Guo, Yi-Chao Zheng, Li-Juan Zhao^*, Hong-Min Liu^*. LSD1: an emerging face in altering the tumor microenvironment and enhancing immune checkpoint therapy. Journal of Biomedical Science. 2023, 30(1):60.

4.Maa Mamun^#, Ying Liu^#, Yin-Ping Geng, Yi-Chao Zheng, Ya Gao, Jian-Gang Sun, Long-Fei Zhao, Li-Juan Zhao^*, Hong-Min Liu^*. Discovery of neddylation E2s inhibitors with therapeutic activity. Oncogenesis. 2023, 12(1):45.

5.Li-Juan Zhao; Ying-Ying Li; Yu-Tong Zhang; Qi-Qi Fan; Hong-Mei Ren; Cheng Zhang; Adil Mar dinoglu; Wen-Chao Chen; Jing-Ru Pang; Dan-Dan Shen; Jun-Wei Wang; Long-Fei Zhao; Jian-Ying Zhang; Zhen-Ya Wang; Yi-Chao Zheng^*; Hong-Min Liu^*; Lysine demethylase LSD1 delivered via small extracellular vesicles promotes gastric cancer cell stemness, EMBO Reports, 2021, 22(8): e50992

6.Li-Juan Zhao; Qi-Qi Fan; Ying-Ying Li; Hong-Mei Ren; Ting Zhang; Shuan Liu; Mamun Maa; Yi-Chao Zheng^*; Hong-Min Liu^*; LSD1 deletion represses gastric cancer migration by upregulating a novel miR-142-5p target protein CD9, Pharmacological Research, 2020, 159(104991)

7.Li-Juan Zhao; Ting Zhang; Xue-Jian Feng; Jiao Chang; Feng-Zhi Suo; Jin-Lian Ma; Ying-Jun Liu; Ying Liu; Yi-Chao Zheng^*; Hong-Min Liu^*; USP28 contributes to the proliferation and metastasis of gastric cancer, Journal of Cellular Biochemistry, 2019, 120(5): 7657-7666