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王作能

编辑:付瀚方    时间:2024-04-17    点击数:

        职称:讲师

        邮箱wang_zuoneng@zzu.edu.cn









个人简介

2014年获得兰州大学学士学位,2017年获得复旦大学硕士学位,2021年获得瑞典皇家理工学院博士学位,20212022年在瑞典皇家理工学院-瑞典卡罗林斯卡医学院从事博士后相关工作。



主要研究方向

1.结构生物学冷冻电镜对膜相关蛋白的结构分析,尤其是冷冻电镜断层扫描技术研究蛋白在细胞膜界面的分子作用机制。

2.重组蜘蛛丝蛋白在生物医学领域的应用

3.长链非编码RNA机体代谢的调控机制研究

 

 

代表性成果

Alastair G. Kerr; Zuoneng Wang; Na Wang; Kelvin H. M. Kwok; Jutta Jalkanen; Alison C. Ludzki; Simon Lecoutre; Dominique Langin; Martin O. Bergo; Ingrid Dahlman; Carsten Mim; Peter Arner; Hui Gao; The long noncoding RNA ADIPINT regulates human adipocyte metabolism via pyruvate carboxylase, Nature Communications, 2022, 13(1): 1-16

Zuoneng Wang; Carsten Mim; Optimizing purification of the peripheral membrane protein FAM92A1 fused to a modified spidroin tag, Protein Expression and Purification, 2021,189(105992)

Zuoneng Wang; Carsten Mim; CryoEM reveals BIN1 (isoform 8) does not bind to single actin filaments in vitro, micropub.biology, 2021, 10(17912)

Zuoneng Wang; Qingyang Zhang; Carsten Mim; Coming of Age: Cryo-Electron Tomography as a Versatile Tool to Generate High-Resolution Structures at Cellular/Biological Interfaces, International Journal of Molecular Sciences, 2021, 22(6177)

Sindhuja Gowrisankaran; Zuoneng Wang; David G. Morgan; Ira Milosevic; Carsten Mim; Cells control BIN1-mediated membrane tubulation by altering the membrane charge, Journal of Molecular Biology, 2020, 432(4): 1235-1250

       Wei Li, Jian-Dong Long, Yuan-Yuan Qian, Yu Long, Xue-Jun Xu, Yu-Jun Wang, Qing Shen, Zuo- Neng Wang, Xi-Cheng Yang, Li Xiao, Hong-Peng Sun, Yu-Long Xu, Yi-Yi Chen, Qiong Xie, Yong- Hui Wang, Li-Ming Shao, Jing-Gen Liu, Zhui-Bai Qiu, Wei Fu. The Pharmacological Heterogeneityof Nepenthone Analogs in Conferring Highly Selective and Potent κ-Opioid Agonistic Activities. ACS Chem. Neurosci. 2017, 8, 4, 766–776

Yanbin S, Xiaoyun Z, Jianyong L, Zuoneng W, Sen C, Ligang C, Yin Q, Huili L, Jingman N. Preparation and pharmacokinetics of an injectable thermosensitive hydrogel of diminazene aceturate. Journal of Drug Delivery Science and Technology, 23 (6) 531-536 2013