河南医学院院长、医学前沿交叉学院院长

天健先进生物医学实验室执行主任

 

 

 

 

主要研究方向

 

主要从事代谢性疾病生理病理机制方面的研究，目前主要集中研究脂质的感应、吸收和储存。在Cell Metabolism、 PNAS、 Nature Communications、Cell Reports和Life Metabolism等杂志发表文章40余篇。 目前担任中国生物物理学会代谢生物学分会理事，中国细胞生物学会细胞代谢分会理事，中国生物化学与分子生物学会代谢专业分会委员，Life Metabolism杂志编委。

代表性成果

1. Xiao-Ting Men#, Qing Shi#, Xiao-Yu Bai#, Yin-Yue Zhao#, Xiao-Xi Liu, Yi-Fan Li, Yu-Xiao Jiang, Ming-Feng Xia, Haobin Ye, Linzhang Huang, Xingrong Du, Ling-Bo Wang, Shuai Chen, Peng Li*, Tong-Jin Zhao*. (2026) DHHC12 Serves as a Critical Nutrient-Responsive Switch that Couples Amino Acid Sensing to Insulin Secretion. Nat Commun.

2. Xiao-Ting Men#, Xiao-Yu Bai#, Yin-Yue Zhao , Yu-Qing Huang , Ding-Yuan Huo , Yu-Xiao Jiang , Ming-Feng Xia , Haobin Ye , Linzhang Huang , Xingrong Du , Hong-Jie Qian, Shuai Chen, Qing Shi*, Tong-Jin Zhao*. (2026) DHHC13 controls lysosomal cholesterol egress through palmitoylating NPC1. Life Metabolism, loag031

3. Yin-Yue Zhao#, Yi-Fan Li#, Jian-Wei Hao, Ning Zhao, Xiao-Ting Men, Xiao-Yu Bai, Rui Tai, Hao-Bin Ye, Xing-Rong Du, Hui-Ling Guo, Juan Wang, Hong-Jie Qian, Tong-Jin Zhao*.(2025) DHHC5 regulates lacteal function and intestinal lipid absorption by maintaining VEGFR2 localization in lipid rafts.Life Metabolism, 4(4):loaf014.

4.Juan Wang#, Huiling Guo#, Lang-Fan Zheng#, Peng Li*, Tong-Jin Zhao*.(2025) Context-specific fatty acid uptake is a finely-tuned multi-level effort.Trends in endocrinology and metabolism. Vol.36 (6), p.577-590

5. Wang J#, Li DL#, Zheng LF, Ren SU, Huang ZQ, Tao Y, Liu Z, Shang Y, Pang D, Guo H, Zeng T, Wang H, Huang H, Du X, Ye H, Zhou HM, Li P, Zhao TJ*. (2024) Dynamic palmitoylation of STX11 controls injury-induced fatty acid uptake to promote muscle regeneration. Dev Cell, 59(3): 384-399.

6. Weng L#, Tang WS#, Wang X#, Gong Y#, Liu C, Hong NN, Tao Y, Li KZ, Liu SN, Jiang W, Li Y, Yao K, Chen L, Huang H, Zhao YZ, Hu ZP, Lu Y, Ye H, Du X, Zhou H*, Li P*, Zhao TJ*. (2024) Surplus fatty acid synthesis increases oxidative stress in adipocytes and induces lipodystrophy. Nat Commun, 15(1): 133.

7.Wang J, Zheng LF, Ren S, Li DL, Chen C, Sun HH, Liu LY, Guo H*, Zhao TJ*. (2023) ARF6 plays a general role in targeting palmitoylated proteins from the Golgi to the plasma membrane. J Cell Sci, 136(15):  jcs261319.

8. Guo H#, Wang J#, Ren S#, Zheng LF#, Zhuang YX, Li DL, Sun HH, Liu LY, Xie C, Wu YY, Wang HR, Deng X, Li P, Zhao TJ* (2022). Targeting EGFR-dependent tumors by disrupting an ARF6-mediated sorting system. Nat Commun, 13: 6004.

9. Wang J, Liang G*, Zhao TJ*. (2022) Adipose triglyceride lipase: The first transacylase for FAHFAs. Life Metabolism, 1: loac016.

10. Wang X#, Liu SY#, Hu GS, Wang HY, Zhang GL, Cen X, Xiang ST, Liu W, Li P, Ye H, Zhao TJ*. (2022) DDB1 prepares brown adipocytes for cold-induced thermogenesis. Life Metabolism, 1, 1: 39-53.

11. Wang X#, Wang HY#, Hu GS#, Tang WS, Weng L, Zhang Y, Guo H, Yao SS, Liu SY, Zhang GL, Han Y, Liu M, Zhang XD, Cen X, Shen HF, Xiao N, Liu CQ, Wang HR, Huang J, Liu W, Li P, Zhao TJ*. (2021) DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity. Cell Rep, 35: 109281.

12. Tang WS#, Weng L#, Wang X#, Liu CQ#, Hu GS, Yin ST, Tao Y, Hong NN, Guo H, Liu W, Wang HR, Zhao TJ*. (2021) The Mediator subunit MED20 organizes the early adipogenic complex to promote development of adipose tissues and diet-induced obesity. Cell Rep, 36: 109314.

13. Hao JW#, Wang J#, Guo H#, Zhao YY, Sun HH, Li YF, Lai XY, Zhao N, Wang X, Xie C, Hong L, Huang X, Wang HR, Li CB, Liang B, Chen S*, Zhao TJ*. (2020) CD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis. Nat Commun, 11: 4765.

14. Wang J#, Hao JW#, Wang X#, Guo H#, Sun HH, Lai XY, Liu LY, Zhu M, Wang HY, Li YF, Yu LY, Xie C, Wang HR, Mo W, Zhou HM, Chen S, Liang G, Zhao TJ*. (2019) DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane. Cell Rep, 26: 209-221.