教授，国家高层次人才青年项目获得者。

主要围绕营养与微生物代谢调控肠道稳态及疾病发生的机制开展研究，形成两个主要研究方向：1）营养与微生物代谢调控肠道稳态；2）肠–外周器官互作与疾病发生机制。团队现有在读博士、硕士研究生6名。近年来，团队成员以第一或通讯作者（含共同）在Gastroenterology、Gut、JCI、Nature Communications、eLife、Theranostics等国际学术期刊发表多篇研究论文。主持国家自然科学基金优秀青年科学基金（海外）项目、国家自然科学基金面上项目、国家自然科学基金青年项目及河南省自然科学基金重点项目等。

代表性成果

（#第一或共同第一）

1. Yuhua Tian, Xin Wang, Zvi Cramer, Joshua Rhoades, Katrina N. Estep, Xiang hui Ma, Stephanie Adams-Tzivelekidis, Bryson W. Katona, F. Brad Johnson, Zhengquan Yu, M. Andres Blanco, Christopher J. Lengner*, Ning Li*. APC and P53 mutations synergize to create a therapeutic vulnerability to NOTUM inhibition in advanced colorectal cancer. GUT Published Online First: 17 August 2023.

2. Yuhua Tian^#, Jiuzhi Xu^#, Yuan Li^#, Ran Zhao, Sujuan Du, Cong Lv, Wei Wu, Ruiqi Liu, Xiaole Sheng, Yongli Song, Xueyun Bi, Guilin Li, Mengzhen Li, Xi Wu, Pengbo Lou, Huiwen You, Wei Cui, Jinyue Sun, Jianwei Shuai, Fazheng Ren, Bing Zhang, Mingzhou Guo, Xiaohua Hou, Kaichun Wu, Lixiang Xue, Hongquan Zhang, Maksim V. Plikus, Yingzi Cong, Christopher J. Lengner, Zhanju Liu*, and Zhengquan Yu*. MicroRNA-31 Reduces Inflammatory Signaling and Promotes Regeneration in Colon Epithelium, and Delivery of Mimics in Microspheres Reduces Colitis in Mice, Gastroenterology. 2019 156:2281–2296.

3.Yuhua Tian^#, Ma X^#, Lv C^#, Sheng X, Li X, Zhao R, Song Y, Andl T, Plikus MV, Sun J, Ren F, Shuai J, Lengner CJ, Cui W, Yu Z*. Stress responsive miR-31 is a major modulator of mouse intestinal stem cells during regeneration and tumorigenesis. eLife.2017 6. pii: e29538.

4.Ma X^#, Tian Y^#, Song Y, Shi J, Xu J, Xiong K, Li J, Xu W, Zhao Y, Shuai J, Chen L, Plikus MV, Lengner CJ, Ren F, Xue L, Yu Z. Msi2 Maintains Quiescent State of Hair Follicle Stem Cells by Directly Repressing the Hh Signaling Pathway. J Invest Dermatol. 2017 May;137(5):1015-1024.

5. Cong Lv^#, Fengyin Li^#, Xiang Li^#, Yuhua Tian^#, Yue Zhang, Xiaole Sheng, Yongli Song, Qingyong Meng, Shukai Yuan, Liming Luan, Thomas Andl, Xu Feng, Baowei Jiao, Mingang Xu, Maksim V. Plikus, Xing Dai, Christopher Lengner, Wei Cui, Fazheng Ren, Jianwei Shuai, Sarah E. Millar, Zhengquan Yu*. MiR-31 promotes mammary stem cell expansion and breast tumorigenesis by suppressing Wnt signaling antagonists. Nature Communications. 2017 8(1): 1036.

6. Lou P^#, Bi X^#, Tian Y^#, Li G, Kang Q, Lv C, Song Y, Xu J, Sheng X, Yang X, Liu R, Meng Q, Ren F, Plikus MV, Liang B, Zhang B, Guo H*, Yu Z*. MiR-22 modulates brown adipocyte thermogenesis by synergistically activating the glycolytic and mTORC1 signaling pathways. Theranostics. 2021 Jan 25;11(8):3607-3623.

7. Kolev HM^#, Tian Y^#, Kim MS, Leu NA, Adams-Tzivelekidis S, Lengner CJ, Li N, Kaestner KH*. A FoxL1-CreERT-2A-tdTomato Mouse Labels Subepithelial Telocytes. Cell Mol Gastroenterol Hepatol. 2021;12(3):1155-1158.e4.