职称：副教授
邮箱：wanglinzz@zzu.edu.cn
地址：河南省郑州市大学路北路40号郑州大学河南医学院
个人简介
王琳，郑州大学医学前沿交叉学院，副教授，博士生导师，主要从事重金属及信号传导通路在细胞恶性转化、新的血管生成和肿瘤发生发展中的作用机理研究。近年来，主持了2项国家自然科学基金和1项河南省优秀青年基金，参与多项国家自然科学基金和省部级科研项目等。作为主要完成人获得河南省自然科学奖二等奖1项和河南省医学科技奖一等奖两项，2019年至2021年在美国爱荷华大学和美国托马斯杰斐逊大学病理学系进行访问学习。目前在Environment International，Seminars in cancer biology，Drug resistance updates和Cancer letters国际知名杂志发表SCI研究论文约40篇。发表论文他引次数约2000次。已指导培养博士及硕士研究生8人。
主要研究方向
环境污染物暴露（重金属等）诱导细胞恶性转化和肿瘤发生发展的机制研究
代表性成果
(1)Zhihao Zhou, Ruike Zhang, Zhaoyang Zhang, Liyuan Zhang, Wei Wang, Wenjing Liu, Chunyang Zhang, Gen Lin, Weimiao Yu, Bo Xu, Lin Wang*(co-corresponding author), Bing-Hua Jiang*. PDK1 elevation was induced by epigenetic modifications of KDM3A and METTL16 to mediate TKI resistance and cancer development.Genes & Diseases. 2025 Nov 25;13(4):101947. (新锐分区一区，IF=14.6)
(2)Zhang Ye, Qiu Jiange, Wang Wei, Sun Fanli, Wang Xue, Liu Wenjing, Jia Xiaoyu, Ji Hongbin, Wang Lin*(co-corresponding author), Jiang Binghua*. Suppression of CYLD by HER3 confers ovarian cancer platinum resistance via inhibiting apoptosis and by inducing drug efflux. Exp Hematol Oncol. 2025 Feb 26;14(1):21. (新锐分区一区，IF=17.5)
(3)Rui-Ke Zhang, Yan Li, Fan-Li Sun, Zhi-Hao Zhou, Yun-Xia Xie, Wen-Jing Liu, Wei Wang, Jian-Ge Qiu, Bing-Hua Jiang*, Lin Wang*(co-corresponding author). RNA methyltransferase NSUN2-mediated m5C methylation promotes Cr(VI)-induced malignant transformation and lung cancer by accelerating metabolism reprogramming. Environment International. 2024 Oct 5:192:109055. (中科院一区，IF=10.3)
(4)Yun-Xia Xie#, Lin Wang# (co-first author), Zhi-Hao Zhou, Wen-Jing Liu, Wei Wang, Jing-Hua Yang, Ming-Liang He, Jian-Ge Qiu*, Bing-Hua Jiang*. m6A RNA methyltransferase METTL16 induces Cr(VI) carcinogenesis and lung cancer development through glutamine biosynthesis and GLUL expression. Journal of Hazardous Materials. 2024 Oct 9:480:136093. (中科院一区，IF=12.2)
(5)Jie Liu, Wei Wang, Kunkun Wang, Wenjing Liu, Yanqiu Zhao, Xiao Han, Lin Wang*(co-corresponding author), Bing-Hua Jiang*. HDAC1 and FOXK1 mediate EGFR-TKI resistance of non-small cell lung cancer through miR-33a silencing. J Transl Med. 2024 Aug 28;22(1):793. (中科院二区，IF=6.1)
(6)Wen-Jing Liu#, Lin Wang# (co-first author), Fan-Li Sun, Feng-Mei Zhou, Rui-Ke Zhang, Jie Liu, Min Zhao, Li-Hong Wang, Yan-Ru Qin, Yan-Qiu Zhao, Jian-Ge Qiu*, Bing-Hua Jiang*. Hexavalent chromium induced metabolic reprogramming, carcinogenesis and tumor progression through PDK1 upregulation. Ecotoxicol Environ Saf. 2024 Nov 16:288:117341. (中科院一区，IF=6.8)
(7)Lin Wang, Rui-ke Zhang, Peng Sang, Yun-Xia Xie, Ye Zhang,Zhi-Hao Zhou, Kun-kun Wang, Feng-Mei Zhou, Xiang-bo Ji, Wen-Jing Liu,Jian-Ge Qiu*, Bing-Hua Jiang*.HK2 and LDHA upregulation mediate hexavalent chromium-induced carcinogenesis, cancer development and prognosis through miR-218 inhibition. Ecotoxicol Environ Saf. 2024 Jul 1;279:116500. (中科院一区，IF=6.8)
(8)Lin Wang, Zhi-Hao Zhou, Yun-Xia Xie, Wen-Jing Liu, Rui-Xiang Zhang, Nan Jiang, Ming-Liang He, Jian-Ge Qiu*, Bing-Hua Jiang*. Dysregulation of MiR-199a/IL8 pathway in chronic Cr (VI)-induced tumor growth and angiogenesis. Ecotoxicology Environmental Safety. 2023 Jun 19;262:115155. (中科院一区，IF=6.8)
(9)Wen-Jing Liu#, Lin Wang#(co-first anthor), Feng-Mei Zhou, Shu-Wen Liu, Wei Wang, Er-Jiang Zhao, Quan-Jun Yao, Wei Li, Yan-Qiu Zhao, Zhi Shi, Jian-Ge Qiu*, Bing-Hua Jiang*. Elevated NOX4 promotes tumorigenesis and acquired EGFR-TKIs resistance via enhancing IL-8/PD-L1 signaling in NSCLC. Drug Resistance Updates. 2023 Jun 22;70:100987. (中科院一区，IF=15.8)
(10)Ye Zhang#, Jian-Ge Qiu#, Xiao-Yu Jia, Yu Ke, Ming-Kun Zhang, David Stieg, Wen-Jing Liu, Ling-Zhi Liu, Lin Wang*(co-corresponding author), Bing-Hua Jiang*. METTL3-mediated N6-methyladenosine modification and HDAC5/YY1 promote IFFO1 downregulation in tumor development and chemo-resistance. Cancer Letters.2023 Jan 28;553:215971. (中科院一区，IF=9.756)
