职称：教授

头衔：国家海外高层次人才计划、博导

邮箱：jinlei_2024@163.com

地址：郑州大学医学科学院

个人简介

金雷教授任郑州大学医学科学院教授、博士生导师。在国际高水平杂志发表论文60余篇，H指数为36，包含第一/通讯作者(或共同)发表在Nature Cell Biology、Molecular Cell、Nature Communications（×4）、Proc Natl Acad Sci（×3）、Cancer Research（×3）、Oncogene（×2）、Cell Death & Disease等24篇，被引超过4000余次。担任国家自然科学基金（NSFC）、澳大利亚国家健康与医学研究委员会（NHMRC）、澳大利亚国家研究理事会（ARC）、奥地利科学基金会（FWF）、英国医学研究委员会(MRC UK)、Worldwide Cancer Research基金会等国家级科研基金的评审专家。

主要研究方向

主要以肺癌、结直肠癌和黑色素瘤等为疾病模型，研究非编码RNA对癌症生存、增殖、代谢和抗药性等方面的调控和作用机制，以及RNA靶向药物的研发。

荣誉及获奖情况

1.Field Leader in Cell Biology. Research Magazine 2023. Australia’s top researchers and research institutions in 250 fields of academic endeavour.

2.Research Excellence Awards. Australian Association of Chinese Biomedical Scientists (AACBS). October 2020.

3.Rising Star Awards. Australian Association of Chinese Biomedical Scientists (AACBS). October 2018.

4.AACR Scholar-in-Training Award in Memory of William Maness. American Association for Cancer Research, April 2017.

代表性成果

1.Liang Xu, Wanying Xiang, Xinyue Wang, Yue Pan, Jing Gao, Jiezhen Yang, Yufei Wang,5 Zhipu Zhu,2 Man Tong,^# Lei Jin,^# Yan Ye^#. Targeting the PHB2-ACSL3 lipid-remodeling axis overcomes cisplatin resistance by restoring ferroptosis in gastric cancer. Adv Sci (Weinh). 2026 Aug 21:e77350.  doi: 10.1002/advs.77350. (^#corresponding author)

2.Wang RJ, Cao LX, He XW, Thorne RF, Wu QC, Ding CY, Zhang JJ, Li MF, Shi ZY, Dong XY, Li J, Li HX, Gao SH, Li JM, Zhang XD, Jin L^#, Fan TL^#, Wu M^#. A CHKA-PML autophagy checkpoint enables tumors to evade glutamine starvation. Proc Natl Acad Sci U S A. 2026 Mar 24;123(12):e2523253123.  doi: 10.1073/pnas.2523253123. Epub 2026 Mar 19. (^#corresponding author)

3.Liang Xu, Xiao Hong Zhao, Yuan Yuan Zhang, Meng Yao Zhang, Long Yue Zhang, Kai Hong Ye, Liu Teng, Man Man Han, Yi Meng Yue, Jiezhen Yang, Rachel Ogle, Jacob Netherton, Deng Tang, Siqi Lan, Mark Baker, Yan Ye, Tao Liu, Yu Fang Wang, Xu Dong Zhang^#, Tianli Fan^#, Lei Jin^#. SNORD80-guided 2'-O-methylation stabilizes the lncRNA GAS5 to regulate cellular stress responses. Proc Natl Acad Sci U S A. 2025 Feb 18;122(7):e2418996122.  doi: 10.1073/pnas.2418996122. (^#corresponding author)

4.Xiao Hong Zhao, Man Man Han, Qian Qian Yan, Yi Meng Yue, Kaihong Ye, Yuan Yuan Zhang, Liu Teng, Liang Xu, Xiao-Jing Shi, Ting La, Yu Chen Feng, Ran Xu, Vinod K. Narayana, David P. De Souza, Lake-Ee Quek, Jeff Holst, Tao Liu, Mark A. Baker, Rick F. Thorne, Xu Dong Zhang^#, Lei Jin^# DNA replication stress underpins the vulnerability to oxidative phosphorylation inhibition in colorectal cancer. Cell Death & Dis. 2025 Jan 14;16(1):16.  doi: 10.1038/s41419-025-07334-4. (^#corresponding author)

5.Zhen Lei, Zhipu Zhu, Zhihui Yao, Xiangyu Dai, Yi Dong, Bing Chen, Songyu Wang, Siyue Wang, Lutterodt Bentum-Ennin, Lei Jin^#, Hao Gu^#, Wanglai Hu^#. Reciprocal interactions between lncRNAs and MYC in colorectal cancer: partners in crime. Cell Death Dis. 2024 Jul 29;15(7):539.  doi: 10.1038/s41419-024-06918-w. (^#corresponding author)