邮箱：lxuetong@zzu.edu.cn

地址：郑州大学天健先进生物医学实验室2号楼808

个人简介

李雪桐，郑州大学医学前沿交叉学院、天健先进生物医学实验室初聘副教授，硕士生导师，博士毕业于西班牙加泰罗尼亚化学研究所（ICIQ）。主要从事绿色有机合成方法学，CO₂催化转化，类药、类天然药物、生物纳米材料的设计、合成及活性评价。相关成果发表在Angewandte Chemie International Edition、ACS Catalysis、Chemical Science等杂志。

主要研究方向

CO₂催化转化合成具有抗肿瘤活性的有机小分子化合物

主持或参加科研项目情况

(1) 教育部第3批博士后海外引才专项，2026.01-2028.12，90万，主持

代表性成果：

1)X. Li, J. Benet-Buchholz, E. C. Escudero-Adán, A. W. Kleij*

Silver-Mediated Cascade Synthesis of Functionalized 1,4-Dihydro-2H-benzo-1,3-oxazin-2-ones from Carbon Dioxide, Angew. Chem. Int. Ed. 2023, 62, e202217803.

2) X. Li^#, A. Villar-Yanez^#, C. Ngassam Tounzoua^#, J. Benet-Buchholz, B. Grignard, C. Bo*, C Detrembleur*, A. W. Kleij*

Cascade Transformation of Carbon Dioxide and Alkyne-1,n-diols into Densely Substituted Cyclic Carbonates, ACS Catal. 2022, 12, 2854‒2860.

3) J. Xie, X. Li, A. W. Kleij*

Pd-catalyzed Stereoselective Tandem Ring-opening Mination/Cyclization of Vinyl γ-Lactones: Access to Caprolactam Diversity, Chem. Sci., 2020, 11, 8839‒8845.

4) X. Li, G. Zhou, X. Du, T. Wang*, Z. Zhang

Catalyst- and Additive-free Cascade Reaction of Isoquinoline N-Oxides with Alkynones: An Approach to Benzoazepino[2,1-a]isoquinoline Derivatives, Org. Lett. 2019, 21, 5630‒5633.

5) X. Li, T. Wang*, Z. Zhang

Synthesis of 4-(Iso)Quinolinyl-3(2H)-furanones from (Iso)Quinoline N-Oxides and 1,4-Diyn-3-ones: A Comparison of Copper Catalysis and Metal-free Reaction, Adv. Synth. Catal. 2019, 361, 696‒701.

6) B. Zhang^#, L. Huang^#, S. Yin, X. Li, T. Xu, B. Zhuang, T. Wang*, Z. Zhang, A. S. K. Hashmi

Cascade C=O/C=C/C‒N Bond Formation: Metal-Free Reaction of 1,4-Diynes and 1-En-4-yn-3-ones with Isoquinoline and Quinoline N-Oxides, Org. Lett. 2017, 19, 4327‒4330.