李朝辉

作者: 时间:2021-03-11 点击数:




 

 

李朝辉,教授,博士生导师

电子邮箱: zhaohui.li@zzu.edu.cn; 电话:0371-67781539

 

 基本信息

李朝辉,博士,河北任丘人。郑州大学化学学院、绿色催化中心、生命分析化学研究所教授,博士生导师。现任化学学院副院长、绿色催化中心副主任、生命分析化学研究所所长。兼任河南省功能分子绿色构建与生物分析国际联合实验室执行主任、郑州大学第一附属医院化学生物学与临床应用研究所执行主任、郑州市功能纳米材料与医学诊疗重点实验室主任。

 

 教育背景

2001.09-2007.03 湖南大学化学生物传感与计量学国家重点实验室,硕博连读研究生,导师:王柯敏教授,谭蔚泓院士

1997.09-2001.06 湖南大学化学化工学院,本科

 

 工作履历

2019.07至今    郑州大学,分析化学学科特聘教授

2012.12至今    郑州大学,教授

2011.08-2012.11 郑州大学,讲师

2009.08-2011.04 美国太平洋西北国家实验室,博士后,合作导师:现华盛顿州立大学教授Yuehe Lin院士

2007.03-2009.08 美国塔夫茨大学,博士后,合作导师:现哈佛大学教授David R. Walt院士

 

 社会兼职

Analytica Chimica Acta编委、Chinese Chemical Letters编委

Journal of Analysis and Testing、《集成技术》、《轻工学报》等青年编委

中国化学会高级会员、中国抗癌协会会员

河南省化学会常务理事

河南省普通高等学校化学专业教学指导委员会委员

全国大学生化学实验创新设计大赛华中赛区竞赛委员会副主任委员

 

 研究领域

荧光纳米探针精准制备及其生命分析应用研究;现场快速检测技术试剂盒研发;数字式单分子检测技术及其临床应用开发。

 

 荣誉奖励

河南省科技术进步一等奖2021

河南省自然科学三等奖(2022

河南省教育厅科技成果一等奖(20222018

河南省教育厅学术技术带头人

河南省高等学校青年骨干教师

河南省优秀硕士学位论文指导教师

 

 教学项目

主持完成河南省高等教育教学改革研究与实践项目、郑州大学教育教学改革研究与实践重点项目多项,作为核心骨干参与教育部高等学校化学类专业教学指导委员会教学研究与实践项目河南省高等教育教学改革研究与实践重大项目、郑州大学教育教学改革研究与实践重大及重点项目多项。

 

 教学成果

国家级虚拟仿真实验教学一流课程(主持人)

河南省教育信息化一等奖2021,第一完成人)

郑州大学教学成果一等奖(2022,第一完成人)

河南省一流本科课程《分析化学》(第一参与人)

郑州大学优秀本科毕业论文(设计)指导教师

 

 科研项目

主持承担国家自然科学基金面上项目2120510821974125、国家自然科学基金青年基金21205108、教育部留学回国人员科研启动基金(教外司留[2013]693、人社部留学人员科技活动项目择优资助(人社函[2013]277、河南省科技研发计划联合基金重点项目222301420007)、河南省科技创新团队(22IRTSTHN002)、河南省产学研合作142107000010、河南省高等学校重点科研项目19A150048、郑州市协同创新重大专项18XTZX12002以及企业横向等科研项目20项;作为主要研究人员参与完成了国家自然科学基金委纳米重大研究计划国家863计划973计划、美国NIH重大项目等研究课题。

 

 科研成果

从事研究工作以来,在Chemical Society ReviewsJournal of the American Chemical SocietyCCS ChemistryAdvanced Functional Materials, Light: Science & Applications Analytical ChemistrySmallACS SensorsAdvanced Healthcare MaterialsACS Applied Materials & InterfacesCarbonChemical CommunicationSensors & Actuators: B. ChemicalChinese Chemical Letters等学术刊物上发表SCI论文200余篇,授权中国发明专利76项,受邀参编英文学术专著4部;产学研协同发展,已开发40余个生物标志物检测试剂盒,用于癌症、阿尔兹海默等重大疾病的早期预警与疗效评估,部分已推广到临床应用研究。

主要代表性论文如下:

Ÿ Yuanqiang Sun, Pengjuan Sun, Lingbo Qu, Zhaohui Li, Wei Guo. Natural Flavylium-Inspired Far-Red to NIR-II Dyes and Their Applications as Fluorescent Probes for Biomedical Sensing. Chemical Society Reviews, 2022, DOI:10.1039/d2cs00179a

Ÿ Yanan Wu, Yating He, Miaomiao Han, Di Zhao, Bojun Liu, Kun Yuan, Hongzhi Sun, Hongmin Meng, and Zhaohui Li. Dual-miRNA-Propelled 3D DNA Walker for Highly Specific and Rapid Discrimination of Breast Cancer Cell Subtypes in Clinical Tissue Samples. CCS Chemistry, 2022, DOI: 10.31635/ccschem.022.202202051.

Ÿ Xin Geng, Yifei Guo, Ying Wang, Yongxin Zhai, Beining Xu, Lingbo Qu, Zhaohui Li. Revealing the adverse effects of trace amount broad-spectrum antimicrobial: a direct and sensitive visualization method based on carbon nanoprobe. Advanced Functional Materials, 2022, DOI:10.1002/adfm.202206753

Ÿ Jingyu Hu, Xin Geng, Yuanqiang Sun, Junli Wang, Yifei Guo, Yuanqiang Sun, Lingbo Qu, Ke Zhang and Zhaohui Li. High-fidelity Carbon Dots Polarity Probes: Revealing the Heterogeneity of Lipids in Oncology. Light: Science & Applications, 2022, DOI: 10.1038/s41377-022-00873-x.

Ÿ Xing Wang, Hongzhi Sun, Bojun Liu, Kemei Jiang, Zhaohui Li, and Hong-Min Meng. DNA Dendrimer-Based Directed 3D Walking Nanomachine for the Sensitive Detection and Intracellular Imaging of miRNA. Analytical Chemistry, 2022, DOI: 10.1021/acs.analchem.2c03963.

Ÿ Ningning Wang, Yaqing Yang, Meng Zhang, Qianqian Zhu, Zhaohui Li. Lysosomal Adenosine Triphosphate-Activated Upconversion Nanoparticle/Carbon Dot Composite for Ratiometric Imaging of Hepatotoxicity. Analytical Chemistry, 2022, DOI: 10.1021/acs.analchem.2c03351

Ÿ Juan Chen, Mingyue Xie, Mingqing Shi, Kun Yuan, Yanna Wu, Hong-Min Meng, Lingbo Qu, Zhaohui Li. Spatial Confinement-drived Double Accelerated DNA Cascade Reaction for Ultrafast and Highly Sensitive in situ Monitoring Exosomal miRNA and Exosomes Tracing. Analytical Chemistry, 2022, 94:2227-2235.

Ÿ Shuo Guo, Yuanqiang Sun, Zhaofan Wu, Ran Yang, Lingbo Qu, Zhaohui Li. Simultaneous Monitoring of Mitochondrial Viscosity and Membrane Potential Based on Fluorescence Changing and Location Switching of Carbon Dots in Living Cells. Carbon, 2022, 195:112-122.

Ÿ Minmin Yan, Deming He, Lishen Zhang, Pengjuan Sun, Yuanqiang Sun, Lingbo Qu, Zhaohui Li. Explorations into the meso-substituents BODIPY-based fluorescent probes for biomedical sensing and imaging. Trends in Analytical Chemistry, 2022, DOI: 10.1016/j.trac.2022.116771

Ÿ Meng Zhang, Ningning Wang, Zhaohui Li. Recent advances in chromophore-assembled upconversion nanoprobes for chemo/biosensing. Trends in Analytical Chemistry, 2022, DOI: 10.1016/j.trac.2022.116602.

Ÿ Kun Yuan, Hongmin Meng,  Yanan Wu, Juan Chen, Hui Xu, Lingbo Qu, Lele Li, Zhaohui Li. Extracellular Milieu and Membrane Receptor Dual-Driven DNA Nanorobot for Accurate in vivo Tumor Imaging. CCS Chemistry, 2021, 3:1679–1691.

Ÿ Zengqiang Liang, Yuan-Qiang Sun, Ruihong Duan, Ran Yang, Ling-Bo Qu, Ke Zhang, Zhaohui Li. Low Polarity Triggered Basic Hydrolysis of Coumarin as An And Logic Gate for Broad-spectrum Cancer Diagnosis. Analytical Chemistry, 2021, 93:12434–12440.

Ÿ Yanan Wu, Zhijun Li, Mingqing Shi, Kun Yuan, Hong-Min Meng, Ling-Bo Qu, Zhaohui Li. Programmable DNAzyme computing for specific in vivo imaging: intracellular stimulus-unlocked target sensing and signal amplification. Analytical Chemistry, 2021, 93:12456-12463.

Ÿ Yan Song, Hongxing Zhang, Xia Wang, Xin Geng, Yuanqiang Sun, Jing Liu, Zhaohui Li. One Stone, Three Birds: pH Triggered Transformation of Aminopyronine and Iminopyronine Based Lysosome Targeting Viscosity Probe for Cancer Visualization. Analytical Chemistry, 2021, 93:1786−1791.

Ÿ Jingyu Hu, Ran Yang, Haoyue Qin, Yuanqiang Sun, Lingbo Qu, Zhaohui Li. Spying on the Polarity Dynamics during Wound Healing of Zebrafish by using Rationally Designed Carbon Dots. Advanced Healthcare Materials, 2021, 10, 2002268.

Ÿ Junli Wang; Yifei Guo; Xin Geng; Jingyu Hu; Minmin Yan; Yuan-Qiang Sun; Ke Zhang; Ling-Bo Qu; Zhaohui Li. Quantitative Structure-Activity Relationship Enables the Rational Design of Lipid Droplet-Targeting Carbon Dots for Visualizing Bisphenol A-Induced Nonalcoholic Fatty Liver Disease-Like Changes. ACS Applied Materials & Interfaces, 2021, 13:44086–44095.

Ÿ Yufei Wang, Hongmin Meng, Zhaohui Li. Near-infrared Inorganic Nanomaterials-based Nanosystem for Photothermal Therapy. Nanoscale, 2021, 13, 8751 – 8772

Ÿ Qiangzeng Liang, Yuanqiang Sun, Huajin Zeng, Kai Sun, Ran Yang, Zhaohui Li, Ke Zhang, Xiaolan Chen, Lingbo Qu. Simultaneous Detection of Human Serum Albumin and Sulfur Dioxide in Living Cells Based on a Catalyzed Michael Addition Reaction. Analytical Chemistry, 2020, 92:16130–1613.

Ÿ Xin Geng, Yuanqiang Sun, Yifei Guo, Yanmin Zhao, Ke Zhang, Lehui Xiao, Lingbo Qu, and Zhaohui Li. Fluorescent carbon dots for in situ monitoring of lysosomal ATP levels. Analytical Chemistry, 2020, 92(11):7940–7946.

Ÿ Xinxin Shi, Hong-Min Meng, Lingbo Qu, and Zhaohui Li. DNAzyme–Metal-Organic Framework Two-Photon Nanoprobe for in situ Monitoring of Apoptosis-associated Zn2+ in living cells and tissues. ACS Sensors, 2020, 5:3150-3157.

Ÿ Yuanqiang Sun, Haoyue Qin, Xin Geng, Ran Yang, Lingbo Qu, Alexander Nti Kani, Zhaohui Li. Rational Design of Far-Red to Near Infrared Emitting Carbon Dots for Ultrafast Lysosomal Polarity Imaging. ACS Applied Materials & Interfaces, 2020, 12:31738–31744.

Ÿ Hong-Min Meng, Xinxin Shi, Juan Chen, Yuhui Gao, Lingbo Qu, Ke Zhang, Xiao-Bing Zhang, and Zhaohui Li. DNA Amplifier-Functionalized Metal-Organic Frameworks for Multiplexed Detection and Imaging of Intracellular mRNA. ACS Sensors, 2020, 5:103-109.

Ÿ Haifang Liu, Yuanqiang Sun, Zhaohui Li, Jie Yang, Aaron Albert Aryee, Lingbo Qu, Dan Du, and Yuehe Lin. Lysosome-Targeted Carbon Dots for Ratiometric Imaging of Formaldehyde in Living Cells. Nanoscale, 2019, 11:8458 - 8463.

Ÿ Wenjing Wang, Huabiao Tang, Yuan Wu, Yinli Zhang, Zhaohui Li. Highly electrocatalytic biosensor based on Hemin@AuNPs/reduced graphene oxide/chitosan nanohybrids for non-enzymatic ultrasensitive detection of hydrogen peroxide in living cells. Biosensors and Bioelectronics, 2019, 132:217-223.

Ÿ Juan Chen, Hongmin Meng, Yuan Tian, Ran Yang, Dan Du, Zhaohui Li, Lingbo Qu and Yuehe Lin. Recent advances in functionalized MnO2 nanosheets for biosensing and biomedicine applications. Nanoscale Horizons, 2019, 4:321-338.

Ÿ Haifang Liu, Jie Yang, Zhaohui Li,  Lehui Xiao, Aaron Albert Aryee, Yuanqiang Sun Ran Yang, Hongmin Meng, Lingbo QuYuehe Lin, and Xiaobing Zhang. Hydrogen-bond induced emission of carbon dots for wash-free nucleus imaging. Analytical Chemistry, 2019, 91:92599265.

Ÿ Xinxin Shi, Hongmin Meng, Yuanqiang Sun, Lingbo Qu, Yuehe Lin, Zhaohui Li, Dan Du. Far-red and near-infrared carbon dots: preparation and applications in biotechnology. Small, 2019, 1901507.

Ÿ Xin Geng, Yuanqiang Sun, Zhaohui Li, Ran Yang, Yanmin Zhao, Yifei Guo, Ying Wang, Siyu Lu and Lingbo Qu. Retrosynthesis of tunable fluorescent carbon dots for precise long-term mitochondrial tracking. Small, 2019, 1901517.

Ÿ Wenjing Wang, Huabiao Tang, Yuan Wu, Yinli Zhang, Zhaohui Li. Highly electrocatalytic biosensor based on Hemin@AuNPs/reduced graphene oxide/chitosan nanohybrids for non-enzymatic ultrasensitive detection of hydrogen peroxide in living cells. Biosensors and Bioelectronics, 2019, 132, 217-223.

Ÿ Hong-Min Meng, Xiao-Xiao Hu, Ge-Zhi Kong, Chan Yang, Ting Fu, Zhaohui Li, and Xiao-Bing Zhang, Aptamer-functionalized nanoscale metal-organic frameworks for targeted photodynamic therapy. Theranostics, 2018, 8(16), 4332-4344.

Ÿ Xin Geng, Zhaohui Li, Yalei Hu, Haifang Liu, Yuanqiang Sun, Hongmin Meng, Yingwen Wang, Lingbo Qu, and Yuehe Lin. One-pot green synthesis of ultrabright N-doped fluorescent silicon nanoparticles for cellular imaging by using ethylenediaminetetraacetic acid disodium salt as an effective reductant. ACS Applied Materials & Interfaces, 2018, 10 (33), pp 27979–27986.

Ÿ Qiyong Cai, Jie Li, Jia Ge, Lin Zhang, Yalei Hu, Zhaohui Li, Lingbo Qu. A rapid fluorescence “switch-on” assay for glutathione detection by using carbon dots–MnO2 nanocomposites. Biosensors and Bioelectronics, 2015, 72:31-36.

Ÿ Lin Zhang, Qiyong Cai, Jie Li, Jia Ge, Junyan Wang, Zhenzhen Dong, Zhaohui Li. A label-free method for detecting biothiols based on poly(thymine)-templated copper nanoparticles. Biosensors and Bioelectronics, 2015, 69:77-82.

Ÿ Ying Wang, Zhaohui Li, Thomas J. Weber, Dehong Hu, Chiann-Tso Lin, Jinghong Li, Yuehe Lin. In Situ Live Cell Sensing of Multiple Nucleotides Exploiting DNA/RNA Aptamers and Graphene Oxide Nanosheets, Analytical Chemistry, 2013, 85:6775-6782

Ÿ Zhaohui Li, Ying Wang, Jun Wang, Zhiwen Tang, Joel G. Pounds, Yuehe Lin. Rapid and Sensitive Protein Detection by Using Portable Fluorescence Biosensor based on Quantum Dots and Lateral Flow Tests Strip. Analytical Chemistry, 2010, 82:7008-7014.

Ÿ Zhaohui Li, Ryan B. Hayman, David R. Walt. Detection of Single-Molecule DNA Hybridization Using Enzymatic Amplification in an Array of Femtoliter-Sized Reaction Vessels. Journal of the American Chemical Society, 2008, 130:12622-12623.

 

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