李朝辉

作者: 时间:2021-03-11 点击数:

 

李朝辉,教授,博士生导师

化学学院副院长、绿色催化中心副主任、生命分析化学研究所所长

Email:zhaohui.li@zzu.edu.cn;Tel(Office):0371-67781539


http://grjl.hnu.edu.cn/content/clxy/images/jy.png基本信息

李朝辉,博士,河北任丘人。郑州大学化学学院、绿色催化中心、生命分析化学研究所教授,博士生导师。现任化学学院副院长、绿色催化中心副主任、生命分析化学研究所所长。兼任河南省功能分子绿色构建与生物分析国际联合实验室执行主任、郑州大学第一附属医院化学生物学与临床应用研究所执行主任、郑州市功能纳米材料与医学诊疗重点实验室主任。


http://grjl.hnu.edu.cn/content/clxy/images/jy.png教育背景

2001.09-2007.03湖南大学化学生物传感与计量学国家重点实验室,硕博连读研究生,导师:王柯敏教授,谭蔚泓院士

1997.09-2001.06湖南大学化学化工学院,本科


http://grjl.hnu.edu.cn/content/clxy/images/jy.png工作履历

2019.07至今郑州大学,分析化学学科特聘教授

2012.12至今郑州大学,教授

2011.08-2012.11郑州大学,讲师

2009.08-2011.04美国太平洋西北国家实验室,博士后研究员,合作导师:现华盛顿州立大学教授Yuehe Lin院士

2007.03-2009.08美国塔夫茨大学,博士后研究员,合作导师:现哈佛大学教授David R. Walt院士


http://grjl.hnu.edu.cn/content/clxy/images/jy.png社会兼职

Analytica Chimica Acta编委

ChineseChemical Letters编委

JournalofAnalysis and Testing青年编委

中国化学会高级会员

中国抗癌协会会员

河南省化学会常务理事

河南省普通高等学校化学专业教学指导委员会委员

全国大学生化学实验创新设计大赛华中赛区竞赛委员会副主任委员


http://grjl.hnu.edu.cn/content/clxy/images/jy.png研究领域

荧光纳米探针精准制备及其生命分析应用研究

现场快速检测技术及其试剂盒研发

数字式单分子微阵列技术及其临床应用研究


http://grjl.hnu.edu.cn/content/clxy/images/jy.png荣誉奖励

河南省科学技术进步一等奖

河南省教育厅科技成果一等奖

河南省教育信息化一等奖

河南省教育厅学术技术带头人

河南省高等学校青年骨干教师

河南省优秀硕士学位论文指导教师


http://grjl.hnu.edu.cn/content/clxy/images/jy.png主持项目

主持承担国家自然科学基金面上项目、国家自然科学基金青年基金、教育部留学回国人员科研启动基金、人社部留学人员科技活动项目择优资助、河南省科技创新团队、河南省产学研合作、河南省高等学校重点科研项目、郑州市协同创新重大专项以及企业横向等科研项目20余项;作为主要研究人员参与完成了国家自然科学基金委纳米重大研究计划,国家863计划,973计划,美国NIH重大项目等研究课题。


http://grjl.hnu.edu.cn/content/clxy/images/jy.png研究成果

从事研究工作以来,在Journal of the American Chemical Society,CCSChemistry,Analytical Chemistry,Small,ACSSensors,ChemicalCommunication,AdvancedHealthy Materials,ACS Applied Materials & Interfaces, Carbon, Chinese Chemical Letters等学术刊物上发表SCI论文180余篇,累计被引用6400余次;授权中国发明专利27项,参编英文学术专著4部;已开发30余个生物标志物检测试剂盒,用于癌症等重大疾病的早期预警与疗效评估,部分已推广到临床应用研究。

代表性论文如下:

1.Juan Chen, Mingyue Xie, Mingqing Shi, Kun Yuan, Yanna Wu, Hong-Min Meng, Lingbo Qu, Zhaohui Li. Spatial Confinement-drived Double Accelerated DNA Cascade Reaction for Ultrafast and Highly Sensitive in situ Monitoring Exosomal miRNA and Exosomes Tracing.Analytical Chemistry, 2022, 94:2227-2235.

2.Shuo Guo, Yuanqiang Sun, Zhaofan Wu, Ran Yang, Lingbo Qu, Zhaohui Li. Simultaneous Monitoring of Mitochondrial Viscosity and Membrane Potential Based on Fluorescence Changing and Location Switching of Carbon Dots in Living Cells.Carbon, 2022, 195:112-122.

3.Meng Zhang, Ningning Wang, Zhaohui Li. Recent advances in chromophore-assembled upconversion nanoprobes for chemo/biosensing.Trends in Analytical Chemistry, 2022, DOI: 10.1016/j.trac.2022.116602.

4.Kun Yuan, Hongmin Meng, Yanan Wu, Juan Chen, Hui Xu, Lingbo Qu, Lele Li, Zhaohui Li. Extracellular Milieu and Membrane Receptor Dual-Driven DNA Nanorobot for Accurate in vivo Tumor Imaging.CCS Chemistry, 2021, 3:1679–1691.

5.Zengqiang Liang, Yuan-Qiang Sun, Ruihong Duan, Ran Yang, Ling-Bo Qu, Ke Zhang, Zhaohui Li. Low Polarity Triggered Basic Hydrolysis of Coumarin as An And Logic Gate for Broad-spectrum Cancer Diagnosis.Analytical Chemistry, 2021, 93:12434–12440.

6.Yanan Wu, Zhijun Li, Mingqing Shi, Kun Yuan, Hong-Min Meng, Ling-Bo Qu, Zhaohui Li. Programmable DNAzyme computing for specific in vivo imaging: intracellular stimulus-unlocked target sensing and signal amplification.Analytical Chemistry, 2021,93:12456-12463.

7.Yan Song, Hongxing Zhang, Xia Wang, Xin Geng, Yuanqiang Sun, Jing Liu, Zhaohui Li. One Stone, Three Birds: pH Triggered Transformation of Aminopyronine and Iminopyronine Based Lysosome Targeting Viscosity Probe for Cancer Visualization.Analytical Chemistry, 2021, 93:1786−1791.

8.Jingyu Hu, Ran Yang, Haoyue Qin, Yuanqiang Sun, Lingbo Qu, Zhaohui Li. Spying on the Polarity Dynamics during Wound Healing of Zebrafish by using Rationally Designed Carbon Dots.Advanced Healthcare Materials, 2021, 10, 2002268.

9.Junli Wang; Yifei Guo; Xin Geng; Jingyu Hu; Minmin Yan; Yuan-Qiang Sun; Ke Zhang; Ling-Bo Qu; Zhaohui Li. Quantitative Structure-Activity Relationship Enables the Rational Design of Lipid Droplet-Targeting Carbon Dots for Visualizing Bisphenol A-Induced Nonalcoholic Fatty Liver Disease-Like Changes.ACS Applied Materials & Interfaces, 2021, 13:44086–44095.

10.Yufei Wang, Hongmin Meng, Zhaohui Li. Near-infrared Inorganic Nanomaterials-based Nanosystem for Photothermal Therapy.Nanoscale, 2021, 13, 8751 – 8772

11.Yanmin Zhao, Xin Geng, Xinxin Shi, Yifei Guo, Yuanqiang Sun, Lingbo Qu, and Zhaohui Li. A fluorescence-switchable carbon dot for reversible turn-on sensing of molecular oxygen.Journal of Materials Chemistry C, 2021, DOI: 10.1039/D1TC00224D.

12.Qiangzeng Liang, Yuanqiang Sun, Huajin Zeng, Kai Sun, Ran Yang, Zhaohui Li, Ke Zhang, Xiaolan Chen, Lingbo Qu. Simultaneous Detection of Human Serum Albumin and Sulfur Dioxide in Living Cells Based on a Catalyzed Michael Addition Reaction.Analytical Chemistry, 2020, 92:16130–1613.

13.Xin Geng, Yuanqiang Sun, Yifei Guo, Yanmin Zhao, Ke Zhang, Lehui Xiao, Lingbo Qu, and Zhaohui Li. Fluorescent carbon dots for in situ monitoring of lysosomal ATP levels.Analytical Chemistry, 2020, 92(11):7940–7946.

14.Xinxin Shi, Hong-Min Meng, Lingbo Qu, and Zhaohui Li. DNAzyme–Metal-Organic Framework Two-Photon Nanoprobe for in situ Monitoring of Apoptosis-associated Zn2+in living cells and tissues.ACS Sensors, 2020, 5:3150-3157.

15.Juan Chen, Jinlu Tang, Hong-Min Meng, Zhuo Liu, Lin Wang, Xin Geng, Yanan Wu, Lingbo Qu and Zhaohui Li. Recognition Triggered Assembly of Split Aptamers to Initiate Hybridization Chain Reaction for Wash-free and Amplified Detection of Exosomes.Chemical Communications, 2020, 56:9024-9027.

16.Yuanqiang Sun, Haoyue Qin, Xin Geng, Ran Yang, Lingbo Qu, Alexander Nti Kani, Zhaohui Li. Rational Design of Far-Red to Near Infrared Emitting Carbon Dots for Ultrafast Lysosomal Polarity Imaging.ACS Applied Materials & Interfaces, 2020,12:31738–31744.

17.Hong-Min Meng, Xinxin Shi, Juan Chen, Yuhui Gao, Lingbo Qu, Ke Zhang, Xiao-Bing Zhang, andZhaohui Li.DNA Amplifier-Functionalized Metal-Organic Frameworks for Multiplexed Detection and Imaging of Intracellular mRNA.ACS Sensors,2020, 5:103-109.

18.Yanan Wu, Hong-Min Meng, Juan Chen, Kemei Jiang, Ran Yang, Yingying Li, Ke Zhang, Lingbo Qu, Xiao-Bing Zhang, and Zhaohui Li. Accelerated DNAzyme-based fluorescent nanoprobe for highly sensitive microRNA detection in live cells.Chemical Communications, 2020, 56:470 – 473.

19.Haifang Liu, Yuanqiang Sun, Zhaohui Li, Jie Yang, Aaron Albert Aryee, Lingbo Qu, Dan Du, and Yuehe Lin. Lysosome-Targeted Carbon Dots for Ratiometric Imaging of Formaldehyde in Living Cells.Nanoscale, 2019, 11:8458 - 8463.

20.Wenjing Wang, Huabiao Tang, Yuan Wu, Yinli Zhang,Zhaohui Li. Highly electrocatalytic biosensor based on Hemin@AuNPs/reduced graphene oxide/chitosan nanohybrids for non-enzymatic ultrasensitive detection of hydrogen peroxide in living cells.Biosensors and Bioelectronics, 2019,132:217-223.

21.Juan Chen, Hongmin Meng, Yuan Tian, Ran Yang, Dan Du,Zhaohui Li, Lingbo Qu and Yuehe Lin. Recent advances in functionalized MnO2nanosheets for biosensing and biomedicine applications.Nanoscale Horizons,2019, 4:321-338.

22.Haifang Liu, Jie Yang, Zhaohui Li, Lehui Xiao, Aaron Albert Aryee, Yuanqiang Sun Ran Yang, Hongmin Meng, Lingbo Qu,Yuehe Lin, and Xiaobing Zhang. Hydrogen-bond induced emission of carbon dots for wash-free nucleus imaging.Analytical Chemistry, 2019, 91:9259−9265.

23.Xinxin Shi, Hongmin Meng, Yuanqiang Sun, Lingbo Qu, Yuehe Lin, Zhaohui Li, Dan Du. Far-red and near-infrared carbon dots: preparation and applications in biotechnology.Small, 2019, 1901507.

24.Xin Geng, Yuanqiang Sun, Zhaohui Li, Ran Yang, Yanmin Zhao, Yifei Guo, Ying Wang, Siyu Lu and Lingbo Qu. Retrosynthesis of tunable fluorescent carbon dots for precise long-term mitochondrial tracking.Small, 2019, 1901517.

25.Hong-Min Meng, Xiao-Xiao Hu, Ge-Zhi Kong, Chan Yang, Ting Fu, Zhaohui Li, and Xiao-Bing Zhang.Aptamer-functionalized nanoscale metal-organic frameworks for targeted photodynamic therapy.Theranostics, 2018, 8(16):4332-4344.

26.Xin Geng, Zhaohui Li, Yalei Hu, Haifang Liu, Yuanqiang Sun, Hongmin Meng, Yingwen Wang, Lingbo Qu, and Yuehe Lin. One-pot green synthesis of ultrabright N-doped fluorescent silicon nanoparticles for cellular imaging by using ethylenediaminetetraacetic acid disodium salt as aneffective reductant.ACSAppliedMaterials &Interfaces,2018, 10:27979–27986.

27.Qiyong Cai, Jie Li, Jia Ge, Lin Zhang, Yalei Hu,Zhaohui Li,Lingbo Qu. A rapid fluorescence “switch-on” assay for glutathione detection by using carbon dots–MnO2nanocomposites.Biosensors and Bioelectronics,2015, 72:31-36.

28.Lin Zhang, Qiyong Cai, Jie Li, Jia Ge, Junyan Wang, Zhenzhen Dong,Zhaohui Li.A label-free method for detecting biothiols based on poly(thymine)-templated copper nanoparticles.Biosensors and Bioelectronics,2015, 69:77-82.

29.Zhaohui Li,Ying Wang, Jun Wang, Zhiwen Tang, Joel G. Pounds, Yuehe Lin. Rapid and Sensitive Protein Detection by Using Portable Fluorescence Biosensor based on Quantum Dots and Lateral Flow Tests Strip.Analytical Chemistry,2010, 82:7008-7014.

30.Zhaohui Li,Ryan B. Hayman, David R. Walt. Detection of Single-Molecule DNA Hybridization Using Enzymatic Amplification in an Array of Femtoliter-Sized Reaction Vessels.Journal of the American Chemical Society, 2008, 130:12622-12623.

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