职称：副教授

        邮箱：hongen_xu@zzu.edu.cn

        地址：郑州市大学路40号医学科学院精准医学中心

个人简介

副教授，硕士生导师。2017年博士毕业于德国慕尼黑工业大学生物信息学专业。2018年3月至2023年4月，郑州大学医学科学院，讲师，拔尖博士，硕士生导师。承担国家自然科学基金青年项目、河南省重点研发与推广专项（科技攻关）、国家卫生健康委出生缺陷预防重点实验室开放课题及河南省医学科技攻关计划联合共建项目各一项。

主要研究方向

遗传性耳聋分子诊断及致病机制研究；遗传性肾病分子诊断；基于深度突变扫描技术的基因变异功能高通量研究；

荣誉及获奖情况

郑州大学科技服务社会先进个人（2021年）

中国康复医学会科技进步奖一等奖（2023年），排名第二

代表性成果

#共同一作，*通讯作者

1.Lu Mao, Yueqiang Wang, Lei An, Beiping Zeng, Yanyan Wang , Dmitrij Frishman, Mengli Liu,Yanyu Chen, Wenxue Tang, Hongen Xu*. Molecular Mechanisms and Clinical Phenotypes of GJB2 Missense Variants. Biology 2023, 12(4):505.

2.Lei An#, Yueqiang Wang#, Guangyao Wu, Zhenxing Wang, Zeyuan Shi, Chang Liu, Chunli Wang, Ming Yi, Chenguang Niu, Shaofeng Duan, Xiaodong Li, Wenxue Tang, Kongming Wu, Shuqing Chen*, Hongen Xu*. Defining the sensitivity landscape of EGFR variants to tyrosine kinase inhibitors. Translational Research. 2023, 255:14-25.

3.Bin Zuo#, Hongen Xu#, Zhaoyu Pan, Lu Mao, Haifeng Feng, Beiping Zeng, Wenxue Tang*, Wei Lu*. A likely pathogenic POLD1 variant associated with mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome in a Chinese patient. BMC Medical Genomics. 2022, 15:220.

4.Beiping Zeng#, Hongen Xu#, Yanan Yu, Siqi Li, Yongan Tian, Tiandong Li, Zengguang Yang, Haili Wang, Guangke Wang, Mingxiu Chang*, Wenxue Tang*. Increased diagnostic yield in a cohort of hearing loss families using a comprehensive stepwise strategy of molecular testing. Frontiers in Genetics, 2022,13:1057293.

5.Junbo Tian#, Jing Zhang#, Zengguang Yang, Shuaisheng Feng, Shujuan Li, Shiqi Ren, Jianxiang Shi, Xinyue Hou, Xia Xue, Bei Yang, Hongen Xu*, Jiancheng Guo*. Genetic Epidemiology of Medication Safety and Efficacy Related Variants in the Central Han Chinese Population With Whole Genome Sequencing. Frontier in Pharmacology. 2022, 12:790832.

6.Haifeng Feng#, Hongen Xu#, Bei Chen#, Shuping Sun, Rongqun Zhai, Beiping Zeng, Wenxue Tang*, Wei Lu*. Genetic and Phenotypic Variability in Chinese Patients With Branchio-Oto-Renal or Branchio-Oto Syndrome. Frontiers in Genetics, 2021, 12:765433.

7.Zhi-Gang Wang#*, Hong-En Xu#, Fu-Min Cheng#, Jie Zhang, Yong-Hua Feng, Dan-Hua Liu, Wen-Jun Shang*, Gui-Wen Feng*. Donor BMSC-derived small extracellular vesicles relieve acute rejection post-renal allograft through transmitting Loc108349490 to dendritic cells. Aging Cell, 2021, 20(10):e13461.

8.Zhigang Wang#, Hongen Xu#, Tianchao Xiang#, Danhua Liu, Fei Xu, Lixiang Zhao, Yonghua Feng, Linan Xu, Jialu Liu, Ye Fang, Huanfei Liu, Ruijun Li, Xinxin Hu,  Jingyuan Guan, Longshan Liu, Guiwen Feng, Qian Shen, Hong Xu, Dmitrij Frishman, Wenxue Tang, Jiancheng Guo*, Jia Rao*, Wenjun Shang*. An accessible insight into genetic findings fortransplantation recipients with suspected genetickidney disease. Npj Genomic Medicine, 2021, 6(1):57.

9.Sen Zhang#, Hongen Xu#, Yongan Tian, Danhua Liu, Xinyue Hou, Beiping Zeng, Bei Chen, Huanfei Liu, Ruijun Li, Xiaohua Li, Bin Zuo, Ryan Tang, Wenxue Tang*. High genetic heterogeneity in Chinese patients with Waardenburg syndrome revealed by next-generation sequencing. Frontiers in Genetics, 2021, 12:643546.

10.Bei Chen#, Hongen Xu#, Yanfang Mi#, Wei Jiang, Dan Guo, Jinhui Zhang, Yulin Zhao, and Wenxue Tang*. Mechanisms of hearing loss and cell death in the cochlea of connexin mutant mice. American Journal of Physiology-Cell Physiology, 2020, 319(3):C569-C578.