职称：研究员

       邮箱：dehai@zzu.edu.cn

       地址：天健先进生物医学实验室2号楼301室

个人简介

李德海，郑州大学医学前沿交叉学院、天健先进生物医学实验室（郑州大学）研究员，博士生导师，博士毕业于暨南大学；主要从事免疫代谢研究，聚焦代谢性疾病与肿瘤演进的免疫调控机制；先后主持国家自然科学基金面上项目、国家自然科学基金青年项目、河南省自然科学优秀青年基金、广东省基础与应用基础研究区域联合青年基金等项目；研究成果发表在Nature、Cell Reports等国际知名期刊。

主要研究方向

主要从事免疫与代谢交互调控的分子机制及其生理功能研究。

已发表代表性论文

1、 Dehai Li#, Jing Zhu#, Mingyue Zhang#, Qiping Shi#, Rong Guo#, Daming Zhang, Pei Zheng, Hua Zhang, Guangqiang Li, Jie Wu, Guodong Sun, Qiong Wen, Jingyi Tan, Zonghua Liu, Xindong Liu, Hengwen Yang*, Hongyun Lu*, Guangchao Cao*, Zhinan Yin*, Qian Wang*. SOSTDC1 downregulation in CD4+ T cells confers protection against obesity-induced insulin resistance. Cell Rep. 2025 Apr 22;44(4):115496.

2、Mingyue Zhang #, Dehai Li #, Jing Zhu #, Xue Xia, Hua Zhang, Jie Wu, Shengli Wang, Anyi Deng, Qiong Wen, Jingyi Tan, Jianlei Hao, Jun Jiang, Xiucong Bao 6, Guodong Sun, Jiajing Lu, Quanli Yang, Hengwen Yang*, Guangchao Cao*, Zhinan Yin*, Qian Wang*.IL-27 disturbs lipid metabolism and restrains mitochondrial activity to inhibit γδ T17 cell-mediated skin inflammation. Cell Death Dis. 2024 Jul 9;15(7):491.

3、Qian Wang#, Dehai Li#, Guangchao Cao#, Qiping Shi#, Jing Zhu, Mingyue Zhang, Hao Cheng, Qiong Wen, Hao Xu, Leqing Zhu, Hua Zhang, Rachel J. Perry, Olga Spadaro, Yunfan Yang, Shengqi He, Yong Chen, Baocheng Wang, Guangqiang Li, Zonghua Liu, Caixian Yang, Xiaoli Wu, Libing Zhou, Qinghua Zhou, Zhenyu Ju, Hongyun Lu, Yongjie Xin, Xiaoyong Yang, Cunchuan Wang, Yong Liu, Gerald I. Shulman, Vishwa D. Dixit, Ligong Lu*, Hengwen Yang*, Richard A. Flavell*, Zhinan Yin*. IL-27 signaling promotes adipocyte thermogenesis and energy expenditure. Nature 600, 314–318.