职称：研究员
邮箱：qiuxiayang625@163.com
地址：天健先进生物医学实验室2号楼304室
个人简介
教育经历：
(1) 2017-09至2021-06，湖南大学，分析化学，博士
(2) 2013-09至2017-06，兰州大学，化学（基础理论班），学士
工作经历
(1) 2023-08至今，郑州大学，医学科学院，直聘研究员
(2) 2021-06至2023-06，中国科学院杭州医学所，博士后
主要研究方向
基于功能核酸的疾病诊疗研究；基于核酸适体的潜在疾病标志物的发现与验证。
荣誉及获奖情况
第十届澳门国际创新发明展金奖
代表性成果
主持项目：
(1) 国家自然科学基金青年科学基金，22205206，2023-01-01至2025-12-31
(2) 中国博士后科学基金会第72批面上资助项目，2022M723203，2022-12-01至2023-05-28
(3) 中国博士后科学基金会博士后创新人才支持计划，BX2021361，2021-05至2023-05
(4) 河南省自然科学基金优青青年基金项目，2025-01至2027-12
发表文章
1. Qiuxia Yang#, Zhenzhen Guo#, Hui Liu#, Ruizi Peng, Liujun Xu, Cheng Bi, Yaqing He, Qiaoling Liu*, Weihong Tan*. A Cascade Signaling Network between Artificial Cells Switching Activity of Synthetic Transmembrane Channels. Journal of the American Chemical Society. 2021, 143, 232-240
2. Qiuxia Yang#, Zhengyu Deng#, Dan Wang, Jiaxuan He, Dailiang Zhang, Yan Tan, Tianhuan Peng, Xueqiang Wang*, Weihong Tan*. Conjugating Aptamer and Mitomycin C with Reductant-Responsive Linker Leading to Synergistically Enhanced Anticancer Effect. Journal of the American Chemical Society. 2020, 142, 2532-2540
3. Qiuxia Yang, Yongbo Peng, Zhegyu Deng, Dailiang Zhang, Chengyu Long, Guorong Zhang, Juan Li, Xue-Qiang Wang*, Weihong Tan*. Regulating the Properties of XQ-2d for Efficient Targeted Delivery of Therapeutic Agents to Pancreatic Cancer. National Science Review, 2023, nwad113
4. Ningyi Li, Zhenzhen Guo, Ruirui Zhang, Yanting Zhang, Taotao Cai, Runwen Qin, Yuting Yao, Zhengmin Fan, Liujun Xu*, Peng Li*, Qiuxia Yang*. Circular Bivalent Aptamer Chimeras Leveraging LDLR-Mediated Lysosomal Shuttling for Targeted Protein Degradation. Journal of Medicinal Chemistry,2026, 69, 18965-18976.
5. Qiuxia Yang*, Ruirui Zhang, Ningyi Li, Bingbing Hao, Runwen Qin, Zhenzhen Guo, Yanting Zhang, Taotao Cai, Yuting Yao, Yixuan Shi, Liujun Xu, Dehai Li, Tongjin Zhao, Peng Li*. Aptamer-Mediated Proximity Labeling (ApMPL) for Spatially Resolved Deciphering Cell Membrane Protein Interactome, Analytical Chemistry, 2026, 98, 7762-7771.
6. Zhenzhen Guo, Huimin Xue, Yang Wang, Yue Qiu, Peiru Chen, Jiali Zhang, Mengyu Huang, Fangmei Zhang*, Qiuxia Yang*, Kaixiang Zhang*. Centipede-Mimetic DNA Nanomachines with Circular Sensing Modules for Spatial Monitoring of Extracellular Metabolites, Analytical Chemistry, 2025, 97, 24050-24057.
7. Zhenzhen Guo*, Yue Qiu, Yang Wang, Jiali Zhang, Xiaotong Jiang, Danyu Wang, Hua Yi, Mengyu Huang, Peiru Chen, Fangmei Zhang, Yan Liang, Fengming Chen, Hua Gao*, Qiuxia Yang*, Kaixiang Zhang*. Integrated DNA logic gate-driven cell membrane confined amplification system for imaging cellular events. Nano Today 2026, 66, 102934.
8. Taotao Cai, Zhenzhen Guo, Runwen Qin, Dehai Li, Yuting Yao, Zhengmin Fan, Yuan Li, Mengbo Wang, Peiru Chen, Jiali Zhang, Zhenzhen Guo, Liujun Xu*, Peng Li*, Qiuxia Yang*, IGFIIR Aptamer-Functionalized Liposomes for Targeted Delivery of Sorafenib to Ameliorate Liver Fibrosis. Langmuir, 2026, 42, 22678-22685.
9. Xia Wang#, Qiuxia Yang#, Chengyu Long, Yan Tan, Yixin Qu, Minhui Su, Sijie Huang, Weihong Tan*, Xue-Qiang Wang*. Anticancer-Active N-Heteroaryl Amines Syntheses: Nucleophilic Amination of N-Heteroaryl Alkyl Ethers with Amines. Organic Letters. 2019, 21, 5111-5115.
10. Zhengyu Deng#, Qiuxia Yang#, Yongbo Peng, Jiaxuan He, Shujuan Xu, Dan Wang, Tianhuan Peng, Ruowen Wang, Xue-Qiang Wang*, Weihong Tan*. Polymeric Engineering of Aptamer−Drug Conjugates for Targeted Cancer Therapy. Bioconjugate Chemistry. 2020, 31, 37-42.
授权专利
1. 谭蔚泓；杨秋霞；付晓艺；彭瑞资；李恒轩；宋明慧；罗昭锋；符婷。用于检测病原微生物的多核酸适体及其组合，2022-6，中国，CN202210754831.2。
2. 谭蔚泓；王雪强；杨秋霞；符婷。一种全硫代磷酸酯修饰的核酸适配体药物偶联物及其制备方法和用途，2020-8，中国，202010537824.8。
3. 谭蔚泓；王雪强；杨秋霞；邓正玉；王丹；何嘉轩；谭燕；符婷。一种核酸适配体药物偶联物及其制备方法和用途，2019-9，中国，CN201910935974.1。
申请专利
1. 李蓬，杨秋霞，张蕊蕊，李宁一，秦润雯，姚玉婷，李媛，王梦博，核酸适体介导的邻近标记探针和方法、细胞膜蛋白相互作用分析方法，中国，申请号：202511518906.7。
2. 李蓬，杨秋霞，李宁一，张蕊蕊，蔡桃桃，姚玉婷，李媛，王梦博，一种基于 LDLR 溶酶体穿梭途径的双特异性核酸适体及其制备方法和应用，中国，申请号：202511717016.9。
3. 李蓬，杨秋霞，张艳婷，姚玉婷，秦润雯，范政敏，李媛，王梦博，一种溶酶体分选信号-核酸适体嵌合体及其制备方法和应用，中国，申请号：202511717058.2。
