个人简介

1995-2000年于沈阳药科大学本科学习，2000-2003年于沈阳药科大学-军事医学科学院生物工程研究所硕士联合培养，2003-2006年于中国科学院上海药物研究所博士培养。2006-2009年复旦大学生物医学研究院博士后，2009-2012年英国利物浦大学博士后，2012-2015年英国邓迪大学博士后，2016-2017年英国伦敦帝国理工学院博士后，2018-2021年英国玛丽女王大学博士后。2021年入职郑州大学。

主要研究方向

主要运用晶体衍射、冷冻电镜、核磁共振、小角散射多种生物物理技术研究泛素系统蛋白复合物结构(E1-E2, E2-E3, E3-substrate, Dub-Ub chain)及其相互作用, 并以其为靶点筛选抗肿瘤药物和抗感染药物。

代表性成果

1) Han C.*, Pao K.*, Kazlauskaite A., Muqit M.K., Virdee S. A versatile strategy for the semisynthetic production of Ser65 phosphorylated ubiquitin and its biochemical and structural characterization. ChemBioChem, 2015, 16(11):1574-1579. * Equal contribution.

2) Antonyuk S.V.*, Han C.*, Eady R.R., Hasnain S. Structures of protein-protein complexes involved in electron transfer. Nature, 2013, 496(7443):123-126. * Equal contribution.

3) Han C., Wright G., Fisher K., Rigby S., Eady R., Hasnain S. Characterization of a novel copper heme c dissimilatory nitrite reductase from Ralstonia pickettii. Biochemical Journal, 2012, 444(2): 219-226.

4) Han C.*, Hu T.*, Wu D., Qu S., Zhou J., Ding J., Shen X., Qu D., Jiang H. X-ray crystallographic and enzymatic analyses of shikimate dehydrogenase from Staphylococcus epidermidis: implications for substrate binding and conformational change. FEBS Journal, 2009, 276(4): 1125-1139. * Equal contribution

5) Han C.*, Zhang J.*, Chen L., Chen K., Shen X., Jiang H. Discovery of Helicobacterpylori shikimate kinase inhibitors: bioassay and molecular modeling. Bioorganic &Medicinal Chemistry, 2007, 15(2): 656-662.* Equal contribution

6) Han C., Wang L., Yu K., Chen L., Hu L., Chen K., Jiang H., Shen X. Biochemical characterization and inhibitor discovery of shikimate dehydrogenase from Helicobacter pylori. FEBS Journal, 2006, 273(20): 4682-4692.

7) Cai J*, Han C*, Hu T, Zhang J, Wu D, Wang F, Liu Y, Ding J, Chen K, Yue J, ShenX, Jiang H. Peptide deformylase is a potential target for anti-Helicobacter pylori drugs: reverse docking, enzymatic assay, and X-ray crystallography validation. Protein Science, 2006, 15(9):2071-2081. * Equal contribution.

8) Han C.*, Wang Q.*, Dong L., Sun H., Peng S., Chen J., Yang Y., Yue J., Shen X., Jiang H. Molecular cloning and characterization of a new peptide deformylase from human pathogenic bacterium Helicobacter pylori. Biochemical and Biophysical Research Communications, 2004, 319(4): 1292-1298. * Equal contribution

9) Pao K.C., Stanley M., Han C., et al. Probes of ubiquitin E3 ligases enable systematic dissection of parkin activation. Nature Chemical Biology, 2016, 12(5):324-331.

10) Stanley M., Han C., Knebel A., Wood N., Virdee S. Orthogonal thiol functionalization at a single atomic center for profiling transthiolation activity of E1 activating enzymes. ACS Chemical Biology, 2015, 10(6):1542-1554.

11) Leferink N., Han C., Antonyuk S., Heyes D., Rigby S., Hough M., Eady R., Scrutton N., Hasnain S. Proton-coupled electron transfer in the catalytic cycle of Alcaligenes xylosoxidans copper-dependent nitrite reductase. Biochemistry, 2011, 50(19): 4121-4131.

12) Lin P., Hu T., Hu J., Yu W., Han C., Zhang J., Qin G., Yu K., Gutz F., Shen X., Jiang H., Qu D. Characterization of peptide deformylase homologues from Staphylococcus epidermidis. Microbiology, 2010, 156(10):3194-3202.

13) Kong Y., Wu D., Bai H., Han C., Chen J., Chen L., Hu L., Jiang H., Shen X. Enzymatic characterization and inhibitor discovery of a new cystathionine (g)-synthase from Helicobacter pylori. Journal of Biochemistry, 2008, 143:59-68.

14) Kong Y., Zhang L., Yang Z., Han C., Hu L., Jiang H., Shen X. Natural product juglone targets three key enzymes from Helicobacter pylori: inhibition assay with crystal structure characterization. Acta Pharmacologica Sinica, 2008, 29(7):870-876.

15) Wu D., Kong Y., Han C., Chen J., Hu L., Jiang H., Shen X. d-Alanine:d-alanine ligase as a new target for the flavonoids quercetin and apigenin. International Journal of Antimicrobial Agents. 2008, 32(5):421-426.

16) Liu W., Han C., Hu L., Chen K., Shen X., Jiang H. Characterization and inhibitor discovery of one novel malonyl-CoA: acyl carrier protein transacylase (MCAT) from Helicobacter pylori. FEBS Letters, 2006, 580: 697-702.

17) Liu W., Luo C., Han C., Peng S., Yang Y., Yue J., Shen X., Jiang H. A new betahydroxyacyl-acyl carrier protein dehydratase (FabZ) from Helicobacter pylori: Molecular cloning, enzymatic characterization, and structural modeling. Biochemical and Biophysical Research Communications, 2005, 333:1078-1086.