个人简介

2018年获得中国科学院大学博士学位；

2018-2023年在以色列魏兹曼科学研究所进行博士后训练；2024年1月加入天健先进生物医学实验室。

主要研究方向

主要从事能量代谢与免疫系统相互作用的研究工作，如代谢性相关疾病对生命健康的长远影响，儿童恶性疾病的免疫学防治等方向，同时致力于单细胞测序技术和空间多组学技术的开发。

代表性成果

共同第一作者论文

1. Lopez R, Li B, Keren-Shaul H, et al. DestVI identifies continuums of cell types in spatial transcriptomics data. Nat Biotechnol. 2022;40(9):1360-1369. (Citation 98, Impact factor 68.16)

2. Jaitin DA, Adlung L, Thaiss CA, Weiner A, Li B, et al. Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner. Cell. 2019;178(3):686-698.e14. (Citation 784, Impact factor 66.85)

3. Li M, Li L, Li B, et al. Brown adipose tissue is the key depot for glucose clearance in microbiota depleted mice. Nat Commun. 2021; 12(1): 4725. (Citation 207, Impact factor 17.69)

4. Li B, Li L, Li M, et al. Microbiota Depletion Impairs Thermogenesis of Brown Adipose Tissue and Browning of White Adipose Tissue. Cell Rep. 2019;26(10):2720-2737.e5. (Citation 209, Impact factor 9.99)

5. Li L, Li B, Li M, Speakman JR. Switching on the furnace: Regulation of heat production in brown adipose tissue. Mol Aspects Med. 2019;68:60-73. (Citation 59, Impact factor 14.23)

6. Li L, Li B, Li M, et al. Brown adipocytes can display a mammary basal myoepithelial cell phenotype in vivo. Mol Metab. 2017;6(10):1198-1211. (Citation 35, Impact factor 8.56)

7. Wang S, Li B, Qiao H, et al. Autophagy-related gene Atg5 is essential for astrocyte differentiation in the developing mouse cortex. EMBO Rep. 2014;15(10):1053-1061. (Citation 61, Impact factor 8.80)

8. Li B, Li Y, et al. Human microglia development in the embryonic brain, Life Medicine. 2022;2(1): 55–57.

部分参与作者论文

1. Kirschenbaum D, Xie K, Ingelfinger F, et al. Time-resolved single-cell transcriptomics defines immune trajectories in glioblastoma. Cell. 2024;187(1):149-165.e23. doi:10.1016/j.cell.2023.11.032

2. Kragesteen BK, Giladi A, David E, et al. The transcriptional and regulatory identity of erythropoietin producing cells. Nat Med. 2023;29(5):1191-1200.

3. Gur C, Wang SY, Sheban F, et al. LGR5 expressing skin fibroblasts define a major cellular hub perturbed in scleroderma. Cell. 2022;185(8):1373-1388.e20.

4. Cohen M, Giladi A, Barboy O, et al. The interaction of CD4⁺ helper T cells with dendritic cells shapes the tumor microenvironment and immune checkpoint blockade response. Nat Cancer. 2022;3(3):303-317.

5. Deczkowska A, David E, Ramadori P, et al. XCR1⁺ type 1 conventional dendritic cells drive liver pathology in non-alcoholic steatohepatitis. Nat Med. 2021;27(6):1043-1054.

6. Cohen YC, Zada M, Wang SY, et al. Identification of resistance pathways and therapeutic targets in relapsed multiple myeloma patients through single-cell sequencing. Nat Med. 2021;27(3):491-503.

7. Wu Y, Li B, Li L, et al. Very-low-protein diets lead to reduced food intake and weight loss, linked to inhibition of hypothalamic mTOR signaling, in mice. Cell Metab. 2021;33(6):1264-1266.

8. Katzenelenbogen Y, Sheban F, Yalin A, et al. Coupled scRNA-Seq and Intracellular Protein Activity Reveal an Immunosuppressive Role of TREM2 in Cancer. Cell. 2020;182(4):872-885.e19.

9. Giladi A, Cohen M, Medaglia C, et al. Dissecting cellular crosstalk by sequencing physically interacting cells. Nat Biotechnol. 2020;38(5):629-637.