个人简介

郑州大学医学科学院分子病理中心/人民医院特聘教授，河南省非编码RNA与肿瘤代谢国际联合实验室负责人；国家优秀青年基金获得者。主要以结直肠癌等肿瘤为疾病模型，探索肿瘤发生、肿瘤代谢与免疫耐受的分子机制。目前以第一/通讯作者(或共同)在Nature Cell Biology、Proc Natl Acad Sci、Cell Metabolism 、Cell Reports、Cancer Communications等高水平杂志发表SCI论文20篇，先后主持国家优青、面上等国自然项目4项、安徽省杰青等各类省级科研项目10余项。

主要研究方向

肿瘤发生机制、肿瘤代谢与免疫耐受机制

课题组成员

技术员：陈冰、董艺；

研究生：田帅、雷震、代翔宇、朱治溥、姚智慧、王崧宇、王思月

代表性成果

[1] Shuang Wu, Xiangyu Dai, Yang Xia, Qingsong Zhao, Heng Zhao, Zhimin Shi, Xin Yin, Xue Liu, Aijie Zhang, Zhihui Yao, Hao Zhang, Qun Li, Rick Francis Thorne, Shangxin Zhang, Weiwei Sheng, *, Wanglai Hu*, Hao Gu*. Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome. Cell Reports (in press, 2024).

[2] Shuang Wu, Zhipu Zhu, Xiangyu Dai, Rick Francis Thorne, Yao Lu*, Hao Gu*, Wanglai Hu*. Reciprocal regulation of lncRNA MEF and c-Myc drives colorectal cancer tumorigenesis. Neoplasia (2024).

[3] Lili Guo, Yang Xia, Zifei Wang, Xiangyu Dai, Hao Li, Hui Xu, Hao Zhang, Qun Li, Ling Zhang, Shangxin Zhang*, Wanglai Hu*, Hao Gu*.FIT Links c-Myc and P53 acetylation by recruiting RBBP7 during carcinogenesis of colorectal cancer. Cancer Gene Therapy (2023).

[4] Anyou Wang, Mingmeng Fang, Hui Jiang, Dongyao Wang, Xuhan Zhang, Baolin Tang, Xiaoyu Zhu, Wanglai Hu*, Xin Liu*. Palbociclib promotes the antitumor activity of Venetoclax plus Azacitidine against acute myeloid leukemia. Biomedicine & Pharmacotherapy (2022).

[5] H. Gu, Y. Xia, L. Guo, Z. Wang, S. Wu, Y. Xu, Y. Zhang, J. Huang, Y. Lei*, W. Hu*, Long non-coding RNA MILNR1 retards colorectal cancer growth by inhibiting c-Myc. Cancer Communications (2020).

[6] Q. Li, Y. Wang, S. Wu, Z. Zhou, X. Ding, R. Shi, R.F. Thorne, X.D. Zhang, W. Hu*, M. Wu*, CircACC1 Regulates Assembly and Activation of AMPK Complex under Metabolic Stress, Cell metabolism (2019).