主要研究方向

主要从事代谢性疾病生理病理机制方面的研究，目前主要集中研究脂质的感应、吸收和储存。在Cell Metabolism、 PNAS、 Nature Communications、Cell Reports和Life Metabolism等杂志发表文章40余篇。 目前担任中国生物物理学会代谢生物学分会理事，中国细胞生物学会细胞代谢分会理事，中国生物化学与分子生物学会代谢专业分会委员，Life Metabolism杂志编委。

代表性成果

Wang J#, Li DL#, Zheng LF, Ren SU, Huang ZQ, Tao Y, Liu Z, Shang Y, Pang D, Guo H, Zeng T, Wang H, Huang H, Du X, Ye H, Zhou HM, Li P, Zhao TJ*. (2024) Dynamic palmitoylation of STX11 controls injury-induced fatty acid uptake to promote muscle regeneration. Dev Cell, 59(3):384-399

Weng L#, Tang WS#, Wang X#, Gong Y#, Liu C, Hong NN, Tao Y, Li KZ, Liu SN, Jiang W, Li Y, Yao K, Chen L, Huang H, Zhao YZ, Hu ZP, Lu Y, Ye H, Du X, Zhou H*, Li P*, Zhao TJ*. (2024) Surplus fatty acid synthesis increases oxidative stress in adipocytes and induces lipodystrophy. Nat Commun 2024;15(1):133.

Wang J, Zheng LF, Ren S, Li DL, Chen C, Sun HH, Liu LY, Guo H*, Zhao TJ*. (2023) ARF6 plays a general role in targeting palmitoylated proteins from the Golgi to the plasma membrane. J Cell Sci. 136(15):jcs261319.

Guo H#, Wang J#, Ren S#, Zheng LF#, Zhuang YX, Li DL, Sun HH, Liu LY, Xie C, Wu YY, Wang HR, Deng X, Li P, Zhao TJ* (2022). Targeting EGFR-dependent tumors by disrupting an ARF6-mediated sorting system. Nature Communications, 13:6004

Wang J, Liang G*, Zhao TJ*. (2022) Adipose triglyceride lipase: The first transacylase for FAHFAs. Life Metabolism, 1:loac016

Wang X#, Liu SY#, Hu GS, Wang HY, Zhang GL, Cen X, Xiang ST, Liu W, Li P, Ye H, Zhao TJ *. (2022) DDB1 prepares brown adipocytes for cold-induced thermogenesis. Life Metabolism, 1,1:39-53

Wang X#, Wang HY#, Hu GS#, Tang WS, Weng L, Zhang Y, Guo H, Yao SS, Liu SY, Zhang GL, Han Y, Liu M, Zhang XD, Cen X, Shen HF, Xiao N, Liu CQ, Wang HR, Huang J, Liu W, Li P, Zhao TJ*. (2021) DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity. Cell Rep. 35:109281

Tang WS#, Weng L#, Wang X#, Liu CQ#, Hu GS, Yin ST, Tao Y, Hong NN, Guo H, Liu W, Wang HR, Zhao TJ*. (2021) The Mediator subunit MED20 organizes the early adipogenic complex to promote development of adipose tissues and diet-induced obesity. Cell Rep. 36:109314

Hao JW#, Wang J#, Guo H#, Zhao YY, Sun HH, Li YF, Lai XY, Zhao N, Wang X, Xie C, Hong L, Huang X, Wang HR, Li CB, Liang B, Chen S*, Zhao TJ*. (2020) CD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis. Nat Commun.11:4765

Wang J#, Hao JW#, Wang X#, Guo H#, Sun HH, Lai XY, Liu LY, Zhu M, Wang HY, Li YF, Yu LY, Xie C, Wang HR, Mo W, Zhou HM, Chen S, Liang G, Zhao TJ*. (2019) DHHC4 and DHHC5 Facilitate Fatty Acid Uptake by Palmitoylating and Targeting CD36 to the Plasma Membrane. Cell Rep.26:209-221