个人简介

2009年毕业于苏州大学，获理学学士学位；2014年毕业于中国科学院昆明动物研究所，获理学博士学位(导师：宿兵研究员)；河南省优秀青年基金获得者；中国遗传学会十一届青年委员会委员；中国遗传学会终身会员；J Genet Genomics、Phenomics、Heliyon、PLoS One、iMeta以及Gene & Protein in Disease等学术期刊编委会成员；国家基金委、教育部学位中心评审专家；近年来主持了3项国家自然科学基金(含两项面上项目)和多项省部级科研项目；在P Natl Acad Sci USA、Mol Biol Evol、Mol Ecol、J Genet Genomics、J Invest Dermatol等国际知名学术期刊发表SCI 研究论文22篇，其中第一和通讯11篇(含共同)；研究结果揭示了东亚人群原肤色和继发性肤色适应的独特遗传机制，填补了相关领域的空白，体现了东亚人群在现代人表型研究体系中的重要地位。

主要研究方向

(1)东亚人群的基因组多样性研究；(2)人群复杂表型和疾病的遗传机制；(3)演化医学。

实验室介绍：https://lab.rjmart.cn/10793/BCC14418BF1C17E2

荣誉及获奖情况

2017年度云南省优秀博士论文；参与主讲的《精准医学基础》入选中央宣传部、国家发展改革委、中央军委政治工作部等单位联合主办的“奋进新时代”主题成就展。

代表性成果

(#共同第一作者; *通讯作者)

1. J. Liu, K.H. Bitsu, Z. Yang*. Skin color: a window into human phenotypic evolution and environmental adaptation. Mol Ecol, Accepted (2024).

2. Y. Pu#, S. Pu#, Y. Chen#, Q. Kong#, X. Liu, Q. Zhao, K. Xu, J. Liu, M. Li, X. Xu, X. Qiao, B. Su, J. Chen*, Z. Yang*, Weakened tanning ability is an important mechanism for evolutionary skin lightening in East Asians. J Genet Genomics, Online (2024).

3. Z. Yang#,*, C. Bai#, Y. Pu#, Q. Kong#, Y. Guo#, Ouzhuluobu, Gengdeng, X. Liu, Q. Zhao, Z. Qiu, W. Zheng, Y. He, Y. Lin, L. Deng, C. Zhang, S. Xu, Y. Peng, K. Xiang, X. Zhang, Baimayangji, Cirenyangji, C. Cui, Baimakangzhuo, Gonggalanzi, Bianba, Y. Pan, J. Xin, Y. Wang, S. Liu, L. Wang, H. Guo, Z. Feng, S. Wang, H. Shi, B. Jiang, T. Wu, X. Qi*, B. Su*, Genetic adaptation of skin pigmentation in highland Tibetans. Proc Natl Acad Sci U S A, 119, e2200421119 (2022).

4. F. Wang#, Q. Luo#, Y. Chen, Y. Liu, K. Xu, K. Adhikari, X. Cai, J. Liu, Y. Li, X. Liu, L. M. Ramirez-Aristeguieta, Z. Yuan, Y. Zhou, F. F. Li, B. Jiang, L. Jin, A. Ruiz-Linares, Z. Yang*, F. Liu*, S. Wang*, A Genome-Wide Scan on Individual Typology Angle Found Variants at SLC24A2 Associated with Skin Color Variation in Chinese Populations. J Invest Dermatol, 142, 1223-1227 e1214 (2022).

5. Z. Yang#, H. Shi#, P. Ma#, S. Zhao, Q. Kong, T. Bian, C. Gong, Q. Zhao, Y. Liu, X. Qi, X. Zhang, Y. Han, J. Liu, Q. Li, H. Chen*, B. Su*, Darwinian Positive Selection on the Pleiotropic Effects of KITLG Explain Skin Pigmentation and Winter Temperature Adaptation in Eurasians. Mol Biol Evol, 35, 2272-2283 (2018).

6. Z. Yang#, H. Zhong#, J. Chen#, X. Zhang#, H. Zhang, X. Luo, S. Xu, H. Chen, D. Lu, Y. Han, J. Li, L. Fu, X. Qi, Y. Peng, K. Xiang, Q. Lin, Y. Guo, M. Li, X. Cao, Y. Zhang, S. Liao, Y. Peng, L. Zhang, X. Guo, S. Dong, F. Liang, J. Wang, A. Willden, H. Seang Aun, B. Serey, T. Sovannary, L. Bunnath, H. Samnom, G. Mardon, Q. Li, A. Meng*, H. Shi*, B. Su*, A Genetic Mechanism for Convergent Skin Lightening during Recent Human Evolution. Mol Biol Evol, 33, 1177-1187 (2016).

7. X. Zhang#, X. Qi#, Z. Yang#, B. Serey, T. Sovannary, L. Bunnath, H. Seang Aun, H. Samnom, H. Zhang, Q. Lin, M. van Oven, H. Shi*, B. Su*, Analysis of mitochondrial genome diversity identifies new and ancient maternal lineages in Cambodian aborigines. Nat Commun, 4, 2599 (2013).

8. X. Qi#, C. Cui#, Y. Peng#, X. Zhang#, Z. Yang#, H. Zhong, H. Zhang, K. Xiang, X. Cao, Y. Wang, Ouzhuluobu, Basang, Ciwangsangbu, Bianba, Gonggalanzi, T. Wu, H. Chen, H. Shi*, B. Su*, Genetic evidence of paleolithic colonization and neolithic expansion of modern humans on the tibetan plateau. Mol Biol Evol, 30, 1761-1778 (2013).

9. Y. Peng#, Z. Yang#, H. Zhang, C. Cui, X. Qi, X. Luo, X. Tao, T. Wu, Ouzhuluobu, Basang, Ciwangsangbu, Danzengduojie, H. Chen, H. Shi*, B. Su*, Genetic variations in Tibetan populations and high-altitude adaptation at the Himalayas. Mol Biol Evol,  28, 1075-1081 (2011).